Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

Snail1 is a key factor controlling epithelial-to-mesenchymal transition and cancer metastasis. While the E3 ligases responsible for Snail1 ubiquitination and degradation have been defined, the deubiquitinating enzyme is unknown. Here Zhou and colleagues show that Dub3 stabilizes Snail1 by removing u...

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Autores principales:	Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana Napier, Qiuying Shi, Jiong Deng, B Mark Evers, Binhua P. Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2fd696d39334f5f9f3e271c34495a71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c2fd696d39334f5f9f3e271c34495a712021-12-02T14:41:10ZDub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation10.1038/ncomms142282041-1723https://doaj.org/article/c2fd696d39334f5f9f3e271c34495a712017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14228https://doaj.org/toc/2041-1723Snail1 is a key factor controlling epithelial-to-mesenchymal transition and cancer metastasis. While the E3 ligases responsible for Snail1 ubiquitination and degradation have been defined, the deubiquitinating enzyme is unknown. Here Zhou and colleagues show that Dub3 stabilizes Snail1 by removing ubiquitin, thus impacting breast cancer cell metastasis.Yadi WuYu WangYiwei LinYajuan LiuYifan WangJianhang JiaPuja SinghYoung-In ChiChi WangChenfang DongWei LiMin TaoDana NapierQiuying ShiJiong DengB Mark EversBinhua P. ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yadi Wu Yu Wang Yiwei Lin Yajuan Liu Yifan Wang Jianhang Jia Puja Singh Young-In Chi Chi Wang Chenfang Dong Wei Li Min Tao Dana Napier Qiuying Shi Jiong Deng B Mark Evers Binhua P. Zhou Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
description	Snail1 is a key factor controlling epithelial-to-mesenchymal transition and cancer metastasis. While the E3 ligases responsible for Snail1 ubiquitination and degradation have been defined, the deubiquitinating enzyme is unknown. Here Zhou and colleagues show that Dub3 stabilizes Snail1 by removing ubiquitin, thus impacting breast cancer cell metastasis.
format	article
author	Yadi Wu Yu Wang Yiwei Lin Yajuan Liu Yifan Wang Jianhang Jia Puja Singh Young-In Chi Chi Wang Chenfang Dong Wei Li Min Tao Dana Napier Qiuying Shi Jiong Deng B Mark Evers Binhua P. Zhou
author_facet	Yadi Wu Yu Wang Yiwei Lin Yajuan Liu Yifan Wang Jianhang Jia Puja Singh Young-In Chi Chi Wang Chenfang Dong Wei Li Min Tao Dana Napier Qiuying Shi Jiong Deng B Mark Evers Binhua P. Zhou
author_sort	Yadi Wu
title	Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
title_short	Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
title_full	Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
title_fullStr	Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
title_full_unstemmed	Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
title_sort	dub3 inhibition suppresses breast cancer invasion and metastasis by promoting snail1 degradation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c2fd696d39334f5f9f3e271c34495a71
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Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

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