Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects

Abstract Pancreatic islet cells have plasticity, such as the abilities to dedifferentiate and transdifferentiate. Islet cell conversion to other characteristic cell is largely determined by transcription factors, but significance of expression patterns of these transcription factors in human islet c...

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Autores principales:	Yukari Fujita, Junji Kozawa, Kenji Fukui, Hiromi Iwahashi, Hidetoshi Eguchi, Iichiro Shimomura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c300c6ee3216488eba26a29cf66434e5
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spelling	oai:doaj.org-article:c300c6ee3216488eba26a29cf66434e52021-12-02T19:13:54ZIncreased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects10.1038/s41598-021-97235-12045-2322https://doaj.org/article/c300c6ee3216488eba26a29cf66434e52021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97235-1https://doaj.org/toc/2045-2322Abstract Pancreatic islet cells have plasticity, such as the abilities to dedifferentiate and transdifferentiate. Islet cell conversion to other characteristic cell is largely determined by transcription factors, but significance of expression patterns of these transcription factors in human islet cells remained unclear. Here, we present the NKX6.1-positive ratio of glucagon-positive cells (NKX6.1+/GCG+ ratio) and the ARX-negative ratio of glucagon-positive cells (ARX−/GCG+ ratio) in 34 patients who were not administered antidiabetic agents. Both of NKX6.1+/GCG+ ratio and ARX−/GCG+ ratio negatively associated with relative beta cell area. And these ratios did not have significant correlation with other parameters including age, body mass index, hemoglobin A1c, fasting plasma glucose level or relative alpha-cell area. Our data demonstrate that these expression ratios of transcription factors in glucagon-positive cells closely correlate with the reduction of beta-cell volume in human pancreas.Yukari FujitaJunji KozawaKenji FukuiHiromi IwahashiHidetoshi EguchiIichiro ShimomuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukari Fujita Junji Kozawa Kenji Fukui Hiromi Iwahashi Hidetoshi Eguchi Iichiro Shimomura Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
description	Abstract Pancreatic islet cells have plasticity, such as the abilities to dedifferentiate and transdifferentiate. Islet cell conversion to other characteristic cell is largely determined by transcription factors, but significance of expression patterns of these transcription factors in human islet cells remained unclear. Here, we present the NKX6.1-positive ratio of glucagon-positive cells (NKX6.1+/GCG+ ratio) and the ARX-negative ratio of glucagon-positive cells (ARX−/GCG+ ratio) in 34 patients who were not administered antidiabetic agents. Both of NKX6.1+/GCG+ ratio and ARX−/GCG+ ratio negatively associated with relative beta cell area. And these ratios did not have significant correlation with other parameters including age, body mass index, hemoglobin A1c, fasting plasma glucose level or relative alpha-cell area. Our data demonstrate that these expression ratios of transcription factors in glucagon-positive cells closely correlate with the reduction of beta-cell volume in human pancreas.
format	article
author	Yukari Fujita Junji Kozawa Kenji Fukui Hiromi Iwahashi Hidetoshi Eguchi Iichiro Shimomura
author_facet	Yukari Fujita Junji Kozawa Kenji Fukui Hiromi Iwahashi Hidetoshi Eguchi Iichiro Shimomura
author_sort	Yukari Fujita
title	Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
title_short	Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
title_full	Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
title_fullStr	Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
title_full_unstemmed	Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
title_sort	increased nkx6.1 expression and decreased arx expression in alpha cells accompany reduced beta-cell volume in human subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c300c6ee3216488eba26a29cf66434e5
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Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects

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