Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects

Abstract Pancreatic islet cells have plasticity, such as the abilities to dedifferentiate and transdifferentiate. Islet cell conversion to other characteristic cell is largely determined by transcription factors, but significance of expression patterns of these transcription factors in human islet c...

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Autores principales: Yukari Fujita, Junji Kozawa, Kenji Fukui, Hiromi Iwahashi, Hidetoshi Eguchi, Iichiro Shimomura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c300c6ee3216488eba26a29cf66434e5
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