Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vac...

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Autores principales:	Niel A. Karrow, Umesh K. Shandilya, Steven Pelech, Lauraine Wagter-Lesperance, Deanna McLeod, Byram Bridle, Bonnie A. Mallard
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 vaccines fetal development neonatal development Medicine R
Acceso en línea:	https://doaj.org/article/c303c08bfbcf41ad83864dfe0e2b9062
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spelling	oai:doaj.org-article:c303c08bfbcf41ad83864dfe0e2b90622021-11-25T19:11:33ZMaternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development10.3390/vaccines91113512076-393Xhttps://doaj.org/article/c303c08bfbcf41ad83864dfe0e2b90622021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1351https://doaj.org/toc/2076-393XVaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing fetus and neonate, remains to be determined. A global effort has been underway to encourage pregnant women to get vaccinated despite the uncertain risk posed to them and their offspring. Given this, post-hoc data collection, potentially for years, will be required to determine the outcomes of COVID-19 and vaccination on the next generation. Most COVID-19 vaccine reactions include injection site erythema, pain, swelling, fatigue, headache, fever and lymphadenopathy, which may be sufficient to affect fetal/neonatal development. In this review, we have explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development. We have followed this with a discussion of the potential for using an ovine model to explore the long-term outcomes of COVID-19 vaccination during the prenatal and neonatal periods.Niel A. KarrowUmesh K. ShandilyaSteven PelechLauraine Wagter-LesperanceDeanna McLeodByram BridleBonnie A. MallardMDPI AGarticleCOVID-19SARS-CoV-2vaccinesfetal developmentneonatal developmentMedicineRENVaccines, Vol 9, Iss 1351, p 1351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 vaccines fetal development neonatal development Medicine R
spellingShingle	COVID-19 SARS-CoV-2 vaccines fetal development neonatal development Medicine R Niel A. Karrow Umesh K. Shandilya Steven Pelech Lauraine Wagter-Lesperance Deanna McLeod Byram Bridle Bonnie A. Mallard Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
description	Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing fetus and neonate, remains to be determined. A global effort has been underway to encourage pregnant women to get vaccinated despite the uncertain risk posed to them and their offspring. Given this, post-hoc data collection, potentially for years, will be required to determine the outcomes of COVID-19 and vaccination on the next generation. Most COVID-19 vaccine reactions include injection site erythema, pain, swelling, fatigue, headache, fever and lymphadenopathy, which may be sufficient to affect fetal/neonatal development. In this review, we have explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development. We have followed this with a discussion of the potential for using an ovine model to explore the long-term outcomes of COVID-19 vaccination during the prenatal and neonatal periods.
format	article
author	Niel A. Karrow Umesh K. Shandilya Steven Pelech Lauraine Wagter-Lesperance Deanna McLeod Byram Bridle Bonnie A. Mallard
author_facet	Niel A. Karrow Umesh K. Shandilya Steven Pelech Lauraine Wagter-Lesperance Deanna McLeod Byram Bridle Bonnie A. Mallard
author_sort	Niel A. Karrow
title	Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
title_short	Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
title_full	Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
title_fullStr	Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
title_full_unstemmed	Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
title_sort	maternal covid-19 vaccination and its potential impact on fetal and neonatal development
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c303c08bfbcf41ad83864dfe0e2b9062
work_keys_str_mv	AT nielakarrow maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT umeshkshandilya maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT stevenpelech maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT laurainewagterlesperance maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT deannamcleod maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT byrambridle maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment AT bonnieamallard maternalcovid19vaccinationanditspotentialimpactonfetalandneonataldevelopment
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Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

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