Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database

Background Atrial fibrillation (AF) and heart failure (HF) often co-exist and are closely intertwined, each condition worsening the other. The temporal relationships between these two disorders have not yet been fully explored. We aimed to address the outcomes of patients hospitalized with HF and AF...

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Autores principales:	Yves Cottin, Brahim Maalem Ben Messaoud, Antoine Monin, Pierre Guilleminot, Arnaud Bisson, Jean-Christophe Eicher, Alexandre Bodin, Julien Herbert, Yves Juillière, Marianne Zeller, Laurent Fauchier
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atrial fibrillation heart failure prognosis Medicine R
Acceso en línea:	https://doaj.org/article/c304f7c159e6495f83ba5fd82f43b785
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spelling	oai:doaj.org-article:c304f7c159e6495f83ba5fd82f43b7852021-11-11T17:43:16ZTemporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database10.3390/jcm102151012077-0383https://doaj.org/article/c304f7c159e6495f83ba5fd82f43b7852021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5101https://doaj.org/toc/2077-0383Background Atrial fibrillation (AF) and heart failure (HF) often co-exist and are closely intertwined, each condition worsening the other. The temporal relationships between these two disorders have not yet been fully explored. We aimed to address the outcomes of patients hospitalized with HF and AF based on the chronology of the onset of the two disorders. Methods From the administrative database for the whole French population, we identified 1,349,638 patients diagnosed with both AF and HF between 2010 and 2018; 956,086 of these AF patients developed HF first (prevalent HF), and 393,552 developed HF after AF (incident HF). The outcome analysis (all-cause death, cardiovascular (CV) death, ischemic stroke or hospitalization for HF) was performed with follow-up starting at the time of last event between AF or HF in the whole cohort and in 427,848 propensity score-matched patients. Results During follow-up (mean follow-up 1.6 ± 1.9 year), matched patients with prevalent HF had a higher risk of all-cause death (21.6 vs. 19.3%/year, hazard ratio (HR) 1.10, 95% CI 1.08–1.11), CV death (7.7 vs. 6.5%/year, HR 1.14, 95% CI 1.12–1.16) as well as re-hospitalization for HF (19.4 vs. 13.2%/year, HR 1.44, 95% CI 1.41–1.46) than those with incident HF. The risk for ischemic stroke was lower in prevalent HF than in incident HF (1.2 vs. 2.4%/year, HR 0.50, 95% CI 0.48–0.52). Conclusions We identified two distinct clinical entities: patients in whom HF preceded AF (prevalent HF) had higher mortality and higher risk of re-hospitalization for HF.Yves CottinBrahim Maalem Ben MessaoudAntoine MoninPierre GuilleminotArnaud BissonJean-Christophe EicherAlexandre BodinJulien HerbertYves JuillièreMarianne ZellerLaurent FauchierMDPI AGarticleatrial fibrillationheart failureprognosisMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5101, p 5101 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation heart failure prognosis Medicine R
spellingShingle	atrial fibrillation heart failure prognosis Medicine R Yves Cottin Brahim Maalem Ben Messaoud Antoine Monin Pierre Guilleminot Arnaud Bisson Jean-Christophe Eicher Alexandre Bodin Julien Herbert Yves Juillière Marianne Zeller Laurent Fauchier Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
description	Background Atrial fibrillation (AF) and heart failure (HF) often co-exist and are closely intertwined, each condition worsening the other. The temporal relationships between these two disorders have not yet been fully explored. We aimed to address the outcomes of patients hospitalized with HF and AF based on the chronology of the onset of the two disorders. Methods From the administrative database for the whole French population, we identified 1,349,638 patients diagnosed with both AF and HF between 2010 and 2018; 956,086 of these AF patients developed HF first (prevalent HF), and 393,552 developed HF after AF (incident HF). The outcome analysis (all-cause death, cardiovascular (CV) death, ischemic stroke or hospitalization for HF) was performed with follow-up starting at the time of last event between AF or HF in the whole cohort and in 427,848 propensity score-matched patients. Results During follow-up (mean follow-up 1.6 ± 1.9 year), matched patients with prevalent HF had a higher risk of all-cause death (21.6 vs. 19.3%/year, hazard ratio (HR) 1.10, 95% CI 1.08–1.11), CV death (7.7 vs. 6.5%/year, HR 1.14, 95% CI 1.12–1.16) as well as re-hospitalization for HF (19.4 vs. 13.2%/year, HR 1.44, 95% CI 1.41–1.46) than those with incident HF. The risk for ischemic stroke was lower in prevalent HF than in incident HF (1.2 vs. 2.4%/year, HR 0.50, 95% CI 0.48–0.52). Conclusions We identified two distinct clinical entities: patients in whom HF preceded AF (prevalent HF) had higher mortality and higher risk of re-hospitalization for HF.
format	article
author	Yves Cottin Brahim Maalem Ben Messaoud Antoine Monin Pierre Guilleminot Arnaud Bisson Jean-Christophe Eicher Alexandre Bodin Julien Herbert Yves Juillière Marianne Zeller Laurent Fauchier
author_facet	Yves Cottin Brahim Maalem Ben Messaoud Antoine Monin Pierre Guilleminot Arnaud Bisson Jean-Christophe Eicher Alexandre Bodin Julien Herbert Yves Juillière Marianne Zeller Laurent Fauchier
author_sort	Yves Cottin
title	Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
title_short	Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
title_full	Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
title_fullStr	Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
title_full_unstemmed	Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database
title_sort	temporal relationship between atrial fibrillation and heart failure development analysis from a nationwide database
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c304f7c159e6495f83ba5fd82f43b785
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Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database

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