The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder characterized by repeated pharyngeal collapse with partial or complete obstruction of the upper airway. This study investigates the biomechanics of upper airway collapse of OSASH patients during natural sleep. Computerized...

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Autores principales:	Liujie Chen, Tan Xiao, Ching Tai Ng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obstructive sleep apnea hypopnea syndrome natural sleep monitoring device one-way valve effect biomechanical simulation individualized treatment Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/c30e5ff4d95f403ca4c780cf600d201a
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spelling	oai:doaj.org-article:c30e5ff4d95f403ca4c780cf600d201a2021-11-25T18:56:35ZThe Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep10.3390/s212274571424-8220https://doaj.org/article/c30e5ff4d95f403ca4c780cf600d201a2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7457https://doaj.org/toc/1424-8220Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder characterized by repeated pharyngeal collapse with partial or complete obstruction of the upper airway. This study investigates the biomechanics of upper airway collapse of OSASH patients during natural sleep. Computerized tomography (CT) scans and data obtained from a device installed on OSASH patients, which is comprised of micro pressure sensors and temperature sensors, are used to develop a pseudo three-dimensional (3D) finite element (FE) model of the upper airway. With consideration of the gravity effect on the soft palate while patients are in a supine position, a fluid–solid coupling analysis is performed using the FE model for the two respiratory modes, eupnea and apnea. The results of this study show that the FE simulations can provide a satisfactory representation of a patient’s actual respiratory physiological processes during natural sleep. The one-way valve effect of the soft palate is one of the important mechanical factors causing upper airway collapse. The monitoring data and FE simulation results obtained in this study provide a comprehensive understanding of the occurrence of OSAHS and a theoretical basis for the individualized treatment of patients. The study demonstrates that biomechanical simulation is a powerful supplementation to clinical monitoring and evaluation.Liujie ChenTan XiaoChing Tai NgMDPI AGarticleobstructive sleep apnea hypopnea syndromenatural sleepmonitoring deviceone-way valve effectbiomechanical simulationindividualized treatmentChemical technologyTP1-1185ENSensors, Vol 21, Iss 7457, p 7457 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea hypopnea syndrome natural sleep monitoring device one-way valve effect biomechanical simulation individualized treatment Chemical technology TP1-1185
spellingShingle	obstructive sleep apnea hypopnea syndrome natural sleep monitoring device one-way valve effect biomechanical simulation individualized treatment Chemical technology TP1-1185 Liujie Chen Tan Xiao Ching Tai Ng The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
description	Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder characterized by repeated pharyngeal collapse with partial or complete obstruction of the upper airway. This study investigates the biomechanics of upper airway collapse of OSASH patients during natural sleep. Computerized tomography (CT) scans and data obtained from a device installed on OSASH patients, which is comprised of micro pressure sensors and temperature sensors, are used to develop a pseudo three-dimensional (3D) finite element (FE) model of the upper airway. With consideration of the gravity effect on the soft palate while patients are in a supine position, a fluid–solid coupling analysis is performed using the FE model for the two respiratory modes, eupnea and apnea. The results of this study show that the FE simulations can provide a satisfactory representation of a patient’s actual respiratory physiological processes during natural sleep. The one-way valve effect of the soft palate is one of the important mechanical factors causing upper airway collapse. The monitoring data and FE simulation results obtained in this study provide a comprehensive understanding of the occurrence of OSAHS and a theoretical basis for the individualized treatment of patients. The study demonstrates that biomechanical simulation is a powerful supplementation to clinical monitoring and evaluation.
format	article
author	Liujie Chen Tan Xiao Ching Tai Ng
author_facet	Liujie Chen Tan Xiao Ching Tai Ng
author_sort	Liujie Chen
title	The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
title_short	The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
title_full	The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
title_fullStr	The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
title_full_unstemmed	The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep
title_sort	biomechanical mechanism of upper airway collapse in osahs patients using clinical monitoring data during natural sleep
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c30e5ff4d95f403ca4c780cf600d201a
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The Biomechanical Mechanism of Upper Airway Collapse in OSAHS Patients Using Clinical Monitoring Data during Natural Sleep

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