Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.

Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo suscepti...

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Autores principales:	Naresh C Laddha, Mitesh Dwivedi, Amina R Gani, Mohmmad Shoab Mansuri, Rasheedunnisa Begum
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3100195977340628c9abaeeafc4e1ae
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spelling	oai:doaj.org-article:c3100195977340628c9abaeeafc4e1ae2021-11-18T08:44:22ZTumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.1932-620310.1371/journal.pone.0081736https://doaj.org/article/c3100195977340628c9abaeeafc4e1ae2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312346/?tool=EBIhttps://doaj.org/toc/1932-6203Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo susceptibility, and expression of TNFB and ICAM1 affects the disease onset and progression. We have earlier reported the role of TNFA in autoimmune pathogenesis of vitiligo, and we now show the involvement of TNFB in vitiligo pathogenesis. The two polymorphisms investigated in the TNFB were in strong linkage disequilibrium and significantly associated with vitiligo. TNFB and ICAM1 transcripts were significantly increased in patients compared to controls. Active vitiligo patients showed significant increase in TNFB transcripts compared to stable vitiligo. The genotype-phenotype analysis revealed that TNFB expression levels were higher in patients with GG and AA genotypes as compared to controls. Patients with the early age of onset and female patients showed higher TNFB and ICAM1 expression. Overall, our findings suggest that the increased TNFB transcript levels in vitiligo patients could result, at least in part, from variations at the genetic level which in turn leads to increased ICAM1 expression. For the first time, we show that TNFB +252A/G and exon 3 C/A polymorphisms are associated with vitiligo susceptibility and influence the TNFB and ICAM1 expression. Moreover, the study also emphasizes influence of TNFB and ICAM1 on the disease progression, onset and gender bias for developing vitiligo.Naresh C LaddhaMitesh DwivediAmina R GaniMohmmad Shoab MansuriRasheedunnisa BegumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81736 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naresh C Laddha Mitesh Dwivedi Amina R Gani Mohmmad Shoab Mansuri Rasheedunnisa Begum Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
description	Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo susceptibility, and expression of TNFB and ICAM1 affects the disease onset and progression. We have earlier reported the role of TNFA in autoimmune pathogenesis of vitiligo, and we now show the involvement of TNFB in vitiligo pathogenesis. The two polymorphisms investigated in the TNFB were in strong linkage disequilibrium and significantly associated with vitiligo. TNFB and ICAM1 transcripts were significantly increased in patients compared to controls. Active vitiligo patients showed significant increase in TNFB transcripts compared to stable vitiligo. The genotype-phenotype analysis revealed that TNFB expression levels were higher in patients with GG and AA genotypes as compared to controls. Patients with the early age of onset and female patients showed higher TNFB and ICAM1 expression. Overall, our findings suggest that the increased TNFB transcript levels in vitiligo patients could result, at least in part, from variations at the genetic level which in turn leads to increased ICAM1 expression. For the first time, we show that TNFB +252A/G and exon 3 C/A polymorphisms are associated with vitiligo susceptibility and influence the TNFB and ICAM1 expression. Moreover, the study also emphasizes influence of TNFB and ICAM1 on the disease progression, onset and gender bias for developing vitiligo.
format	article
author	Naresh C Laddha Mitesh Dwivedi Amina R Gani Mohmmad Shoab Mansuri Rasheedunnisa Begum
author_facet	Naresh C Laddha Mitesh Dwivedi Amina R Gani Mohmmad Shoab Mansuri Rasheedunnisa Begum
author_sort	Naresh C Laddha
title	Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
title_short	Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
title_full	Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
title_fullStr	Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
title_full_unstemmed	Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.
title_sort	tumor necrosis factor b (tnfb) genetic variants and its increased expression are associated with vitiligo susceptibility.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c3100195977340628c9abaeeafc4e1ae
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Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.

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