Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeuti...

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Autores principales:	Lu Cui, Shih-Yu Chen, Tristan Lerbs, Jin-Wook Lee, Pablo Domizi, Sydney Gordon, Yong-hun Kim, Garry Nolan, Paola Betancur, Gerlinde Wernig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c31003c7ba9446ada3f7ab8183096f6b
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spelling	oai:doaj.org-article:c31003c7ba9446ada3f7ab8183096f6b2021-12-02T18:24:58ZActivation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity10.1038/s41467-020-16466-42041-1723https://doaj.org/article/c31003c7ba9446ada3f7ab8183096f6b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16466-4https://doaj.org/toc/2041-1723Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications.Lu CuiShih-Yu ChenTristan LerbsJin-Wook LeePablo DomiziSydney GordonYong-hun KimGarry NolanPaola BetancurGerlinde WernigNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
description	Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications.
format	article
author	Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig
author_facet	Lu Cui Shih-Yu Chen Tristan Lerbs Jin-Wook Lee Pablo Domizi Sydney Gordon Yong-hun Kim Garry Nolan Paola Betancur Gerlinde Wernig
author_sort	Lu Cui
title	Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
title_short	Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
title_full	Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
title_fullStr	Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
title_full_unstemmed	Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
title_sort	activation of jun in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c31003c7ba9446ada3f7ab8183096f6b
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Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

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