Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration

Abstract Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Vira...

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Autores principales:	Andrew Campbell, Jessica M. Hogestyn, Christopher J. Folts, Brittany Lopez, Christoph Pröschel, David Mock, Margot Mayer-Pröschel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c31090ca82e3444daa7a868ec7878e14
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spelling	oai:doaj.org-article:c31090ca82e3444daa7a868ec7878e142021-12-02T12:30:19ZExpression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration10.1038/s41598-017-04432-y2045-2322https://doaj.org/article/c31090ca82e3444daa7a868ec7878e142017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04432-yhttps://doaj.org/toc/2045-2322Abstract Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.Andrew CampbellJessica M. HogestynChristopher J. FoltsBrittany LopezChristoph PröschelDavid MockMargot Mayer-PröschelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrew Campbell Jessica M. Hogestyn Christopher J. Folts Brittany Lopez Christoph Pröschel David Mock Margot Mayer-Pröschel Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
description	Abstract Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.
format	article
author	Andrew Campbell Jessica M. Hogestyn Christopher J. Folts Brittany Lopez Christoph Pröschel David Mock Margot Mayer-Pröschel
author_facet	Andrew Campbell Jessica M. Hogestyn Christopher J. Folts Brittany Lopez Christoph Pröschel David Mock Margot Mayer-Pröschel
author_sort	Andrew Campbell
title	Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_short	Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_full	Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_fullStr	Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_full_unstemmed	Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_sort	expression of the human herpesvirus 6a latency-associated transcript u94a disrupts human oligodendrocyte progenitor migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c31090ca82e3444daa7a868ec7878e14
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Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration

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