Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case

Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or aty...

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Autores principales:	K V Vinu Balraam, Adnan Masood, Nidhi Garg, Venkatesan Somasundaram
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	anemia cold antibody hemolytic respiratory failure Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/c319845da4e545b885e31d5d0909b8dc
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spelling	oai:doaj.org-article:c319845da4e545b885e31d5d0909b8dc2021-11-12T10:08:28ZCoomb's negative cold agglutinin disease: A rare report of an incidentally detected case0973-62471998-356510.4103/ajts.AJTS_78_20https://doaj.org/article/c319845da4e545b885e31d5d0909b8dc2021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=233;epage=236;aulast=Balraamhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.K V Vinu BalraamAdnan MasoodNidhi GargVenkatesan SomasundaramWolters Kluwer Medknow Publicationsarticleanemiacold antibodyhemolyticrespiratory failureDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 233-236 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia cold antibody hemolytic respiratory failure Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	anemia cold antibody hemolytic respiratory failure Diseases of the blood and blood-forming organs RC633-647.5 K V Vinu Balraam Adnan Masood Nidhi Garg Venkatesan Somasundaram Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
description	Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.
format	article
author	K V Vinu Balraam Adnan Masood Nidhi Garg Venkatesan Somasundaram
author_facet	K V Vinu Balraam Adnan Masood Nidhi Garg Venkatesan Somasundaram
author_sort	K V Vinu Balraam
title	Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
title_short	Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
title_full	Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
title_fullStr	Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
title_full_unstemmed	Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case
title_sort	coomb's negative cold agglutinin disease: a rare report of an incidentally detected case
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/c319845da4e545b885e31d5d0909b8dc
work_keys_str_mv	AT kvvinubalraam coombsnegativecoldagglutinindiseaseararereportofanincidentallydetectedcase AT adnanmasood coombsnegativecoldagglutinindiseaseararereportofanincidentallydetectedcase AT nidhigarg coombsnegativecoldagglutinindiseaseararereportofanincidentallydetectedcase AT venkatesansomasundaram coombsnegativecoldagglutinindiseaseararereportofanincidentallydetectedcase
_version_	1718431076199694336

Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case

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