Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria

Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria

Abstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However,...

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Autores principales: Marilou Tétard, Jacqueline Milet, Sébastien Dechavanne, Nadine Fievet, Dominique Dorin-Semblat, Jacques Elion, Rick M. Fairhurst, Philippe Deloron, Nicaise Tuikue-Ndam, Benoît Gamain
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c31a1bd9e7014fffac41459587679ee6
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spelling oai:doaj.org-article:c31a1bd9e7014fffac41459587679ee62021-12-02T16:06:59ZHeterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria10.1038/s41598-017-01495-92045-2322https://doaj.org/article/c31a1bd9e7014fffac41459587679ee62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01495-9https://doaj.org/toc/2045-2322Abstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9 g, p = 0.08), or during the first half of pregnancy (654.3 g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas.Marilou TétardJacqueline MiletSébastien DechavanneNadine FievetDominique Dorin-SemblatJacques ElionRick M. FairhurstPhilippe DeloronNicaise Tuikue-NdamBenoît GamainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marilou Tétard
Jacqueline Milet
Sébastien Dechavanne
Nadine Fievet
Dominique Dorin-Semblat
Jacques Elion
Rick M. Fairhurst
Philippe Deloron
Nicaise Tuikue-Ndam
Benoît Gamain
Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
description Abstract Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9 g, p = 0.08), or during the first half of pregnancy (654.3 g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas.
format article
author Marilou Tétard
Jacqueline Milet
Sébastien Dechavanne
Nadine Fievet
Dominique Dorin-Semblat
Jacques Elion
Rick M. Fairhurst
Philippe Deloron
Nicaise Tuikue-Ndam
Benoît Gamain
author_facet Marilou Tétard
Jacqueline Milet
Sébastien Dechavanne
Nadine Fievet
Dominique Dorin-Semblat
Jacques Elion
Rick M. Fairhurst
Philippe Deloron
Nicaise Tuikue-Ndam
Benoît Gamain
author_sort Marilou Tétard
title Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
title_short Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
title_full Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
title_fullStr Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
title_full_unstemmed Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
title_sort heterozygous hbac but not hbas is associated with higher newborn birthweight among women with pregnancy-associated malaria
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c31a1bd9e7014fffac41459587679ee6
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