Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and H...

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Autores principales:	Wenjing Yang, Tianming Yu, Xiangsheng Huang, Anthony J. Bilotta, Leiqi Xu, Yao Lu, Jiaren Sun, Fan Pan, Jia Zhou, Wenbo Zhang, Suxia Yao, Craig L. Maynard, Nagendra Singh, Sara M. Dann, Zhanju Liu, Yingzi Cong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c31a59e08ef446ffa06978b9286f2500
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spelling	oai:doaj.org-article:c31a59e08ef446ffa06978b9286f25002021-12-02T19:12:26ZIntestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity10.1038/s41467-020-18262-62041-1723https://doaj.org/article/c31a59e08ef446ffa06978b9286f25002020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18262-6https://doaj.org/toc/2041-1723Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and HIF1α-mediated mechanism that protects mice from intestinal inflammation.Wenjing YangTianming YuXiangsheng HuangAnthony J. BilottaLeiqi XuYao LuJiaren SunFan PanJia ZhouWenbo ZhangSuxia YaoCraig L. MaynardNagendra SinghSara M. DannZhanju LiuYingzi CongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjing Yang Tianming Yu Xiangsheng Huang Anthony J. Bilotta Leiqi Xu Yao Lu Jiaren Sun Fan Pan Jia Zhou Wenbo Zhang Suxia Yao Craig L. Maynard Nagendra Singh Sara M. Dann Zhanju Liu Yingzi Cong Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
description	Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and HIF1α-mediated mechanism that protects mice from intestinal inflammation.
format	article
author	Wenjing Yang Tianming Yu Xiangsheng Huang Anthony J. Bilotta Leiqi Xu Yao Lu Jiaren Sun Fan Pan Jia Zhou Wenbo Zhang Suxia Yao Craig L. Maynard Nagendra Singh Sara M. Dann Zhanju Liu Yingzi Cong
author_facet	Wenjing Yang Tianming Yu Xiangsheng Huang Anthony J. Bilotta Leiqi Xu Yao Lu Jiaren Sun Fan Pan Jia Zhou Wenbo Zhang Suxia Yao Craig L. Maynard Nagendra Singh Sara M. Dann Zhanju Liu Yingzi Cong
author_sort	Wenjing Yang
title	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
title_short	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
title_full	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
title_fullStr	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
title_full_unstemmed	Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
title_sort	intestinal microbiota-derived short-chain fatty acids regulation of immune cell il-22 production and gut immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c31a59e08ef446ffa06978b9286f2500
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Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

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