Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy

Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with b...

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Autores principales:	Yassine Merad, Hichem Derrar, Sarah Tabouri, Faiza Berexi-Reguig
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	purulent discharge docetaxel onychomycosis candida guilliermondii Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c31abe6e08304127bd14563ccb36b1e7
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spelling	oai:doaj.org-article:c31abe6e08304127bd14563ccb36b1e72021-11-18T11:08:46ZCandida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy1662-657510.1159/000519695https://doaj.org/article/c31abe6e08304127bd14563ccb36b1e72021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519695https://doaj.org/toc/1662-6575Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with breast cancer admitted in our institution for onycholysis. Because of the stage and histology of breast cancer, neoadjuvant chemotherapy was initiated. The patient received 8 cycles of Taxotere and Adriamycin (AT), and she underwent a modified radical mastectomy. Three months later, the patient developed evidence of onycholysis, involving all the fingernails. We observed the following changes in nails of all the digits in both hands: onycholysis, dystrophy, oedema, and exudate. Nail scraping and purulent discharge were collected and cultured on Sabouraud medium. Physical features of the colonies and biochemical tests (Auxacolor©) revealed Candida guilliermondii as the sole etiologic agent of onychomycosis. This case details an onycholysis in a breast cancer case successfully managed solely with amorolfine lacquer. This clinical and mycological presentation should alert the clinician to the possibility of onychomycosis induced by docetaxel chemotherapy.Yassine MeradHichem DerrarSarah TabouriFaiza Berexi-ReguigKarger Publishersarticlepurulent dischargedocetaxelonychomycosiscandida guilliermondiiNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1530-1535 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	purulent discharge docetaxel onychomycosis candida guilliermondii Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	purulent discharge docetaxel onychomycosis candida guilliermondii Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
description	Onychomycosis has been shown to have a higher incidence in cancer patients. Nail toxicity is a quite common side effect of anticancer agents. Taxotere© is a chemotherapeutic known to cause great incidence of nail change and has a role in subungual suppuration. We report on a 52-year-old woman with breast cancer admitted in our institution for onycholysis. Because of the stage and histology of breast cancer, neoadjuvant chemotherapy was initiated. The patient received 8 cycles of Taxotere and Adriamycin (AT), and she underwent a modified radical mastectomy. Three months later, the patient developed evidence of onycholysis, involving all the fingernails. We observed the following changes in nails of all the digits in both hands: onycholysis, dystrophy, oedema, and exudate. Nail scraping and purulent discharge were collected and cultured on Sabouraud medium. Physical features of the colonies and biochemical tests (Auxacolor©) revealed Candida guilliermondii as the sole etiologic agent of onychomycosis. This case details an onycholysis in a breast cancer case successfully managed solely with amorolfine lacquer. This clinical and mycological presentation should alert the clinician to the possibility of onychomycosis induced by docetaxel chemotherapy.
format	article
author	Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig
author_facet	Yassine Merad Hichem Derrar Sarah Tabouri Faiza Berexi-Reguig
author_sort	Yassine Merad
title	Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
title_short	Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
title_full	Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
title_fullStr	Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
title_full_unstemmed	Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy
title_sort	candida guilliermondii onychomycosis involving fingernails in a breast cancer patient under docetaxel chemotherapy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/c31abe6e08304127bd14563ccb36b1e7
work_keys_str_mv	AT yassinemerad candidaguilliermondiionychomycosisinvolvingfingernailsinabreastcancerpatientunderdocetaxelchemotherapy AT hichemderrar candidaguilliermondiionychomycosisinvolvingfingernailsinabreastcancerpatientunderdocetaxelchemotherapy AT sarahtabouri candidaguilliermondiionychomycosisinvolvingfingernailsinabreastcancerpatientunderdocetaxelchemotherapy AT faizaberexireguig candidaguilliermondiionychomycosisinvolvingfingernailsinabreastcancerpatientunderdocetaxelchemotherapy
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Candida guilliermondii Onychomycosis Involving Fingernails in a Breast Cancer Patient under Docetaxel Chemotherapy

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