Walking down Skeletal Muscle Lane: From Inflammasome to Disease

Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin do...

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Autores principales:	Nicolas Dubuisson, Romain Versele, María A. Davis-López de Carrizosa, Camille M. Selvais, Sonia M. Brichard, Michel Abou-Samra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skeletal muscle NLRP3 inflammasome pyroptosis metabolic syndrome sepsis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c31c9aae9525475bbf1f29b986dc33c1
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id	oai:doaj.org-article:c31c9aae9525475bbf1f29b986dc33c1
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spelling	oai:doaj.org-article:c31c9aae9525475bbf1f29b986dc33c12021-11-25T17:10:30ZWalking down Skeletal Muscle Lane: From Inflammasome to Disease10.3390/cells101130232073-4409https://doaj.org/article/c31c9aae9525475bbf1f29b986dc33c12021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3023https://doaj.org/toc/2073-4409Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders.Nicolas DubuissonRomain VerseleMaría A. Davis-López de CarrizosaCamille M. SelvaisSonia M. BrichardMichel Abou-SamraMDPI AGarticleskeletal muscleNLRP3inflammasomepyroptosismetabolic syndromesepsisBiology (General)QH301-705.5ENCells, Vol 10, Iss 3023, p 3023 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle NLRP3 inflammasome pyroptosis metabolic syndrome sepsis Biology (General) QH301-705.5
spellingShingle	skeletal muscle NLRP3 inflammasome pyroptosis metabolic syndrome sepsis Biology (General) QH301-705.5 Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra Walking down Skeletal Muscle Lane: From Inflammasome to Disease
description	Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders.
format	article
author	Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra
author_facet	Nicolas Dubuisson Romain Versele María A. Davis-López de Carrizosa Camille M. Selvais Sonia M. Brichard Michel Abou-Samra
author_sort	Nicolas Dubuisson
title	Walking down Skeletal Muscle Lane: From Inflammasome to Disease
title_short	Walking down Skeletal Muscle Lane: From Inflammasome to Disease
title_full	Walking down Skeletal Muscle Lane: From Inflammasome to Disease
title_fullStr	Walking down Skeletal Muscle Lane: From Inflammasome to Disease
title_full_unstemmed	Walking down Skeletal Muscle Lane: From Inflammasome to Disease
title_sort	walking down skeletal muscle lane: from inflammasome to disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c31c9aae9525475bbf1f29b986dc33c1
work_keys_str_mv	AT nicolasdubuisson walkingdownskeletalmusclelanefrominflammasometodisease AT romainversele walkingdownskeletalmusclelanefrominflammasometodisease AT mariaadavislopezdecarrizosa walkingdownskeletalmusclelanefrominflammasometodisease AT camillemselvais walkingdownskeletalmusclelanefrominflammasometodisease AT soniambrichard walkingdownskeletalmusclelanefrominflammasometodisease AT michelabousamra walkingdownskeletalmusclelanefrominflammasometodisease
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Walking down Skeletal Muscle Lane: From Inflammasome to Disease

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