Mechanochemical control of epidermal stem cell divisions by B-plexins
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.
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Nature Portfolio
2021
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oai:doaj.org-article:c31e77abae1d4cc9839c925693d0c2fb2021-12-02T13:15:06ZMechanochemical control of epidermal stem cell divisions by B-plexins10.1038/s41467-021-21513-92041-1723https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21513-9https://doaj.org/toc/2041-1723It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.Chen JiangAhsan JavedLaura KaiserMichele M. NavaRui XuDominique T. BrandtDandan ZhaoBenjamin MayerJavier Fernández-BaldovinosLuping ZhouCarsten HößKovilen SawmynadenArkadiusz OleksyDavid MatthewsLee S. WeinsteinHeidi HahnHermann-Josef GrönePeter L. GraumannCarien M. NiessenStefan OffermannsSara A. WickströmThomas WorzfeldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chen Jiang Ahsan Javed Laura Kaiser Michele M. Nava Rui Xu Dominique T. Brandt Dandan Zhao Benjamin Mayer Javier Fernández-Baldovinos Luping Zhou Carsten Höß Kovilen Sawmynaden Arkadiusz Oleksy David Matthews Lee S. Weinstein Heidi Hahn Hermann-Josef Gröne Peter L. Graumann Carien M. Niessen Stefan Offermanns Sara A. Wickström Thomas Worzfeld Mechanochemical control of epidermal stem cell divisions by B-plexins |
| description |
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation. |
| format |
article |
| author |
Chen Jiang Ahsan Javed Laura Kaiser Michele M. Nava Rui Xu Dominique T. Brandt Dandan Zhao Benjamin Mayer Javier Fernández-Baldovinos Luping Zhou Carsten Höß Kovilen Sawmynaden Arkadiusz Oleksy David Matthews Lee S. Weinstein Heidi Hahn Hermann-Josef Gröne Peter L. Graumann Carien M. Niessen Stefan Offermanns Sara A. Wickström Thomas Worzfeld |
| author_facet |
Chen Jiang Ahsan Javed Laura Kaiser Michele M. Nava Rui Xu Dominique T. Brandt Dandan Zhao Benjamin Mayer Javier Fernández-Baldovinos Luping Zhou Carsten Höß Kovilen Sawmynaden Arkadiusz Oleksy David Matthews Lee S. Weinstein Heidi Hahn Hermann-Josef Gröne Peter L. Graumann Carien M. Niessen Stefan Offermanns Sara A. Wickström Thomas Worzfeld |
| author_sort |
Chen Jiang |
| title |
Mechanochemical control of epidermal stem cell divisions by B-plexins |
| title_short |
Mechanochemical control of epidermal stem cell divisions by B-plexins |
| title_full |
Mechanochemical control of epidermal stem cell divisions by B-plexins |
| title_fullStr |
Mechanochemical control of epidermal stem cell divisions by B-plexins |
| title_full_unstemmed |
Mechanochemical control of epidermal stem cell divisions by B-plexins |
| title_sort |
mechanochemical control of epidermal stem cell divisions by b-plexins |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb |
| work_keys_str_mv |
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| _version_ |
1718393411308879872 |