Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

Metabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.

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Autores principales:	Diem Hong Tran, Herman I. May, Qinfeng Li, Xiang Luo, Jian Huang, Guangyu Zhang, Erica Niewold, Xiaoding Wang, Thomas G. Gillette, Yingfeng Deng, Zhao V. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c31f594008b74ae48fead9d2a15351c9
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spelling	oai:doaj.org-article:c31f594008b74ae48fead9d2a15351c92021-12-02T14:40:54ZChronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling10.1038/s41467-020-15640-y2041-1723https://doaj.org/article/c31f594008b74ae48fead9d2a15351c92020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15640-yhttps://doaj.org/toc/2041-1723Metabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.Diem Hong TranHerman I. MayQinfeng LiXiang LuoJian HuangGuangyu ZhangErica NiewoldXiaoding WangThomas G. GilletteYingfeng DengZhao V. WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
description	Metabolic remodeling plays an important role in pathological cardiac hypertrophy. Here, the authors show that hexosamine biosynthetic pathway is elevated in the heart by pressure overload, which contributes to heart failure by persistent activation of mTOR.
format	article
author	Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang
author_facet	Diem Hong Tran Herman I. May Qinfeng Li Xiang Luo Jian Huang Guangyu Zhang Erica Niewold Xiaoding Wang Thomas G. Gillette Yingfeng Deng Zhao V. Wang
author_sort	Diem Hong Tran
title	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_short	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_full	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_fullStr	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_full_unstemmed	Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
title_sort	chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c31f594008b74ae48fead9d2a15351c9
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Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

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