Emerging roles of suppressor of cytokine signaling 3 in human cancers

As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-inducible protein that inhibits cytokine signaling in a variety of signaling pathways. Increasing evidence shows that SOCS3 regulates tumor development through multiple pathological and physiological processes. It...

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Autores principales:	Lirui Dai, Zian Li, Yiran Tao, Wulong Liang, Weihua Hu, Shaolong Zhou, Xudong Fu, Xinjun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SOCS3 Cancer MicroRNAs Target gene Target therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c3222832d7294909a792060b1887acbb
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spelling	oai:doaj.org-article:c3222832d7294909a792060b1887acbb2021-11-14T04:28:58ZEmerging roles of suppressor of cytokine signaling 3 in human cancers0753-332210.1016/j.biopha.2021.112262https://doaj.org/article/c3222832d7294909a792060b1887acbb2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010465https://doaj.org/toc/0753-3322As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-inducible protein that inhibits cytokine signaling in a variety of signaling pathways. Increasing evidence shows that SOCS3 regulates tumor development through multiple pathological and physiological processes. It is worth mentioning that SOCS3 negatively regulates JAK/STAT signaling by binding to JAK/cytokine receptors or phosphorylation docking sites on STAT receptors, thus preventing tumor cell proliferation and inhibiting tumor cell invasion and metastasis. The kinase inhibitory region KIR of SOCS3 is the key to JAK inhibition. In addition, SOCS3 may also regulate tumor progression through other molecules or signaling pathways, such as microRNAs (miRNAs), IL-6 and NF-κB signaling pathway. MicroRNAs inhibit SOCS3 expression by binding to the 3’ untranslated region of SOCS3 mRNA, thus regulating tumor development processes, including tumor cell proliferation, invasion, metastasis, differentiation, cell cycle and apoptosis, as well as tumor metastasis and chemotherapy resistance. On the whole, SOCS3 acts as an inhibitor of the majority of tumors through various pathways. In the present review, the role of SOCS3 in multitudinous tumors was comprehensively summarized, the molecular mechanisms and modes of action of SOCS3 in tumors were discussed, and the association between SOCS3 expression and the clinical characteristics of patients with cancer were emphasized.Lirui DaiZian LiYiran TaoWulong LiangWeihua HuShaolong ZhouXudong FuXinjun WangElsevierarticleSOCS3CancerMicroRNAsTarget geneTarget therapyTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112262- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SOCS3 Cancer MicroRNAs Target gene Target therapy Therapeutics. Pharmacology RM1-950
spellingShingle	SOCS3 Cancer MicroRNAs Target gene Target therapy Therapeutics. Pharmacology RM1-950 Lirui Dai Zian Li Yiran Tao Wulong Liang Weihua Hu Shaolong Zhou Xudong Fu Xinjun Wang Emerging roles of suppressor of cytokine signaling 3 in human cancers
description	As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-inducible protein that inhibits cytokine signaling in a variety of signaling pathways. Increasing evidence shows that SOCS3 regulates tumor development through multiple pathological and physiological processes. It is worth mentioning that SOCS3 negatively regulates JAK/STAT signaling by binding to JAK/cytokine receptors or phosphorylation docking sites on STAT receptors, thus preventing tumor cell proliferation and inhibiting tumor cell invasion and metastasis. The kinase inhibitory region KIR of SOCS3 is the key to JAK inhibition. In addition, SOCS3 may also regulate tumor progression through other molecules or signaling pathways, such as microRNAs (miRNAs), IL-6 and NF-κB signaling pathway. MicroRNAs inhibit SOCS3 expression by binding to the 3’ untranslated region of SOCS3 mRNA, thus regulating tumor development processes, including tumor cell proliferation, invasion, metastasis, differentiation, cell cycle and apoptosis, as well as tumor metastasis and chemotherapy resistance. On the whole, SOCS3 acts as an inhibitor of the majority of tumors through various pathways. In the present review, the role of SOCS3 in multitudinous tumors was comprehensively summarized, the molecular mechanisms and modes of action of SOCS3 in tumors were discussed, and the association between SOCS3 expression and the clinical characteristics of patients with cancer were emphasized.
format	article
author	Lirui Dai Zian Li Yiran Tao Wulong Liang Weihua Hu Shaolong Zhou Xudong Fu Xinjun Wang
author_facet	Lirui Dai Zian Li Yiran Tao Wulong Liang Weihua Hu Shaolong Zhou Xudong Fu Xinjun Wang
author_sort	Lirui Dai
title	Emerging roles of suppressor of cytokine signaling 3 in human cancers
title_short	Emerging roles of suppressor of cytokine signaling 3 in human cancers
title_full	Emerging roles of suppressor of cytokine signaling 3 in human cancers
title_fullStr	Emerging roles of suppressor of cytokine signaling 3 in human cancers
title_full_unstemmed	Emerging roles of suppressor of cytokine signaling 3 in human cancers
title_sort	emerging roles of suppressor of cytokine signaling 3 in human cancers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c3222832d7294909a792060b1887acbb
work_keys_str_mv	AT liruidai emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT zianli emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT yirantao emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT wulongliang emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT weihuahu emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT shaolongzhou emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT xudongfu emergingrolesofsuppressorofcytokinesignaling3inhumancancers AT xinjunwang emergingrolesofsuppressorofcytokinesignaling3inhumancancers
_version_	1718430040069242880

Emerging roles of suppressor of cytokine signaling 3 in human cancers

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