A functional dissociation of the left frontal regions that contribute to single word production tasks

Controversy surrounds the interpretation of higher activation for pseudoword compared to word reading in the left precentral gyrus and pars opercularis. Specifically, does activation in these regions reflect: (1) the demands on sublexical assembly of articulatory codes, or (2) retrieval effort becau...

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Autores principales:	Justyna O. Ekert, Diego L. Lorca-Puls, Andrea Gajardo-Vidal, Jennifer T. Crinion, Thomas M.H. Hope, David W. Green, Cathy J. Price
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c323085fd26f482eae7cd153ba4a7d08
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spelling	oai:doaj.org-article:c323085fd26f482eae7cd153ba4a7d082021-11-22T04:18:56ZA functional dissociation of the left frontal regions that contribute to single word production tasks1095-957210.1016/j.neuroimage.2021.118734https://doaj.org/article/c323085fd26f482eae7cd153ba4a7d082021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010065https://doaj.org/toc/1095-9572Controversy surrounds the interpretation of higher activation for pseudoword compared to word reading in the left precentral gyrus and pars opercularis. Specifically, does activation in these regions reflect: (1) the demands on sublexical assembly of articulatory codes, or (2) retrieval effort because the combinations of articulatory codes are unfamiliar? Using fMRI, in 84 neurologically intact participants, we addressed this issue by comparing reading and repetition of words (W) and pseudowords (P) to naming objects (O) from pictures or sounds. As objects do not provide sublexical articulatory cues, we hypothesis that retrieval effort will be greater for object naming than word repetition/reading (which benefits from both lexical and sublexical cues); while the demands on sublexical assembly will be higher for pseudoword production than object naming.We found that activation was: (i) highest for pseudoword reading [P>O&W in the visual modality] in the anterior part of the ventral precentral gyrus bordering the precentral sulcus (vPCg/vPCs), consistent with the sublexical assembly of articulatory codes; but (ii) as high for object naming as pseudoword production [P&O>W] in dorsal precentral gyrus (dPCg) and the left inferior frontal junction (IFJ), consistent with retrieval demands and cognitive control.In addition, we dissociate the response properties of vPCg/vPCs, dPCg and IFJ from other left frontal lobe regions that are activated during single word speech production. Specifically, in both auditory and visual modalities: a central part of vPCg (head and face area) was more activated for verbal than nonverbal stimuli [P&W>O]; and the pars orbitalis and inferior frontal sulcus were most activated during object naming [O>W&P]. Our findings help to resolve a previous discrepancy in the literature, dissociate three functionally distinct parts of the precentral gyrus, and refine our knowledge of the functional anatomy of speech production in the left frontal lobe.Justyna O. EkertDiego L. Lorca-PulsAndrea Gajardo-VidalJennifer T. CrinionThomas M.H. HopeDavid W. GreenCathy J. PriceElsevierarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118734- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Justyna O. Ekert Diego L. Lorca-Puls Andrea Gajardo-Vidal Jennifer T. Crinion Thomas M.H. Hope David W. Green Cathy J. Price A functional dissociation of the left frontal regions that contribute to single word production tasks
description	Controversy surrounds the interpretation of higher activation for pseudoword compared to word reading in the left precentral gyrus and pars opercularis. Specifically, does activation in these regions reflect: (1) the demands on sublexical assembly of articulatory codes, or (2) retrieval effort because the combinations of articulatory codes are unfamiliar? Using fMRI, in 84 neurologically intact participants, we addressed this issue by comparing reading and repetition of words (W) and pseudowords (P) to naming objects (O) from pictures or sounds. As objects do not provide sublexical articulatory cues, we hypothesis that retrieval effort will be greater for object naming than word repetition/reading (which benefits from both lexical and sublexical cues); while the demands on sublexical assembly will be higher for pseudoword production than object naming.We found that activation was: (i) highest for pseudoword reading [P>O&W in the visual modality] in the anterior part of the ventral precentral gyrus bordering the precentral sulcus (vPCg/vPCs), consistent with the sublexical assembly of articulatory codes; but (ii) as high for object naming as pseudoword production [P&O>W] in dorsal precentral gyrus (dPCg) and the left inferior frontal junction (IFJ), consistent with retrieval demands and cognitive control.In addition, we dissociate the response properties of vPCg/vPCs, dPCg and IFJ from other left frontal lobe regions that are activated during single word speech production. Specifically, in both auditory and visual modalities: a central part of vPCg (head and face area) was more activated for verbal than nonverbal stimuli [P&W>O]; and the pars orbitalis and inferior frontal sulcus were most activated during object naming [O>W&P]. Our findings help to resolve a previous discrepancy in the literature, dissociate three functionally distinct parts of the precentral gyrus, and refine our knowledge of the functional anatomy of speech production in the left frontal lobe.
format	article
author	Justyna O. Ekert Diego L. Lorca-Puls Andrea Gajardo-Vidal Jennifer T. Crinion Thomas M.H. Hope David W. Green Cathy J. Price
author_facet	Justyna O. Ekert Diego L. Lorca-Puls Andrea Gajardo-Vidal Jennifer T. Crinion Thomas M.H. Hope David W. Green Cathy J. Price
author_sort	Justyna O. Ekert
title	A functional dissociation of the left frontal regions that contribute to single word production tasks
title_short	A functional dissociation of the left frontal regions that contribute to single word production tasks
title_full	A functional dissociation of the left frontal regions that contribute to single word production tasks
title_fullStr	A functional dissociation of the left frontal regions that contribute to single word production tasks
title_full_unstemmed	A functional dissociation of the left frontal regions that contribute to single word production tasks
title_sort	functional dissociation of the left frontal regions that contribute to single word production tasks
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c323085fd26f482eae7cd153ba4a7d08
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A functional dissociation of the left frontal regions that contribute to single word production tasks

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