Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
Cancer cells employ a variety of ways to escape the immune system. Here, the authors show that ovarian cancer cells produce small extracellular vescicles containing arginase 1 that are taken up by dendritic cells in the draining lymph nodes, resulting in inhibition of antigen-specific T-cell prolife...
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Nature Portfolio
2019
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oai:doaj.org-article:c326eb351422420292defaecb97f14102021-12-02T16:57:42ZSmall extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma10.1038/s41467-019-10979-32041-1723https://doaj.org/article/c326eb351422420292defaecb97f14102019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10979-3https://doaj.org/toc/2041-1723Cancer cells employ a variety of ways to escape the immune system. Here, the authors show that ovarian cancer cells produce small extracellular vescicles containing arginase 1 that are taken up by dendritic cells in the draining lymph nodes, resulting in inhibition of antigen-specific T-cell proliferation.Malgorzata Czystowska-KuzmiczAnna SosnowskaDominika NowisKavita RamjiMarta SzajnikJustyna Chlebowska-TuzEwa WolinskaPawel GajMagdalena GrazulZofia PilchAbdessamad ZerrouqiAgnieszka Graczyk-JarzynkaKarolina SoroczynskaSzczepan CierniakRobert KoktyszEsther ElishaevSlawomir GrucaArtur StefanowiczRoman BlaszczykBartlomiej BorekAnna GzikTheresa WhitesideJakub GolabNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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Science Q Malgorzata Czystowska-Kuzmicz Anna Sosnowska Dominika Nowis Kavita Ramji Marta Szajnik Justyna Chlebowska-Tuz Ewa Wolinska Pawel Gaj Magdalena Grazul Zofia Pilch Abdessamad Zerrouqi Agnieszka Graczyk-Jarzynka Karolina Soroczynska Szczepan Cierniak Robert Koktysz Esther Elishaev Slawomir Gruca Artur Stefanowicz Roman Blaszczyk Bartlomiej Borek Anna Gzik Theresa Whiteside Jakub Golab Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| description |
Cancer cells employ a variety of ways to escape the immune system. Here, the authors show that ovarian cancer cells produce small extracellular vescicles containing arginase 1 that are taken up by dendritic cells in the draining lymph nodes, resulting in inhibition of antigen-specific T-cell proliferation. |
| format |
article |
| author |
Malgorzata Czystowska-Kuzmicz Anna Sosnowska Dominika Nowis Kavita Ramji Marta Szajnik Justyna Chlebowska-Tuz Ewa Wolinska Pawel Gaj Magdalena Grazul Zofia Pilch Abdessamad Zerrouqi Agnieszka Graczyk-Jarzynka Karolina Soroczynska Szczepan Cierniak Robert Koktysz Esther Elishaev Slawomir Gruca Artur Stefanowicz Roman Blaszczyk Bartlomiej Borek Anna Gzik Theresa Whiteside Jakub Golab |
| author_facet |
Malgorzata Czystowska-Kuzmicz Anna Sosnowska Dominika Nowis Kavita Ramji Marta Szajnik Justyna Chlebowska-Tuz Ewa Wolinska Pawel Gaj Magdalena Grazul Zofia Pilch Abdessamad Zerrouqi Agnieszka Graczyk-Jarzynka Karolina Soroczynska Szczepan Cierniak Robert Koktysz Esther Elishaev Slawomir Gruca Artur Stefanowicz Roman Blaszczyk Bartlomiej Borek Anna Gzik Theresa Whiteside Jakub Golab |
| author_sort |
Malgorzata Czystowska-Kuzmicz |
| title |
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| title_short |
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| title_full |
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| title_fullStr |
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| title_full_unstemmed |
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma |
| title_sort |
small extracellular vesicles containing arginase-1 suppress t-cell responses and promote tumor growth in ovarian carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c326eb351422420292defaecb97f1410 |
| work_keys_str_mv |
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