IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes f...

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Autores principales: Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, The International IBD Genetics Consortium, Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c3282316b00248958032424db0e3a0c7
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spelling oai:doaj.org-article:c3282316b00248958032424db0e3a0c72021-12-02T15:34:41ZIBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes10.1038/s41467-018-04365-82041-1723https://doaj.org/article/c3282316b00248958032424db0e3a0c72018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04365-8https://doaj.org/toc/2041-1723Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.Yukihide MomozawaJulia DmitrievaEmilie ThéâtreValérie DeffontaineSouad RahmouniBenoît CharloteauxFrançois CrinsElisa DocampoMahmoud ElansaryAnn-Stephan GoriChristelle LecutRob MarimanMyriam MniCécile OuryIlya AltukhovDmitry AlexeevYuri AulchenkoLeila AmininejadGerd BoumaFrank HoentjenMark LöwenbergBas OldenburgMarieke J. PierikAndrea E. vander Meulen-de JongC. Janneke van der WoudeMarijn C. VisschedijkThe International IBD Genetics ConsortiumMark LathropJean-Pierre HugotRinse K. WeersmaMartine De VosDenis FranchimontSeverine VermeireMichiaki KuboEdouard LouisMichel GeorgesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yukihide Momozawa
Julia Dmitrieva
Emilie Théâtre
Valérie Deffontaine
Souad Rahmouni
Benoît Charloteaux
François Crins
Elisa Docampo
Mahmoud Elansary
Ann-Stephan Gori
Christelle Lecut
Rob Mariman
Myriam Mni
Cécile Oury
Ilya Altukhov
Dmitry Alexeev
Yuri Aulchenko
Leila Amininejad
Gerd Bouma
Frank Hoentjen
Mark Löwenberg
Bas Oldenburg
Marieke J. Pierik
Andrea E. vander Meulen-de Jong
C. Janneke van der Woude
Marijn C. Visschedijk
The International IBD Genetics Consortium
Mark Lathrop
Jean-Pierre Hugot
Rinse K. Weersma
Martine De Vos
Denis Franchimont
Severine Vermeire
Michiaki Kubo
Edouard Louis
Michel Georges
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
description Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.
format article
author Yukihide Momozawa
Julia Dmitrieva
Emilie Théâtre
Valérie Deffontaine
Souad Rahmouni
Benoît Charloteaux
François Crins
Elisa Docampo
Mahmoud Elansary
Ann-Stephan Gori
Christelle Lecut
Rob Mariman
Myriam Mni
Cécile Oury
Ilya Altukhov
Dmitry Alexeev
Yuri Aulchenko
Leila Amininejad
Gerd Bouma
Frank Hoentjen
Mark Löwenberg
Bas Oldenburg
Marieke J. Pierik
Andrea E. vander Meulen-de Jong
C. Janneke van der Woude
Marijn C. Visschedijk
The International IBD Genetics Consortium
Mark Lathrop
Jean-Pierre Hugot
Rinse K. Weersma
Martine De Vos
Denis Franchimont
Severine Vermeire
Michiaki Kubo
Edouard Louis
Michel Georges
author_facet Yukihide Momozawa
Julia Dmitrieva
Emilie Théâtre
Valérie Deffontaine
Souad Rahmouni
Benoît Charloteaux
François Crins
Elisa Docampo
Mahmoud Elansary
Ann-Stephan Gori
Christelle Lecut
Rob Mariman
Myriam Mni
Cécile Oury
Ilya Altukhov
Dmitry Alexeev
Yuri Aulchenko
Leila Amininejad
Gerd Bouma
Frank Hoentjen
Mark Löwenberg
Bas Oldenburg
Marieke J. Pierik
Andrea E. vander Meulen-de Jong
C. Janneke van der Woude
Marijn C. Visschedijk
The International IBD Genetics Consortium
Mark Lathrop
Jean-Pierre Hugot
Rinse K. Weersma
Martine De Vos
Denis Franchimont
Severine Vermeire
Michiaki Kubo
Edouard Louis
Michel Georges
author_sort Yukihide Momozawa
title IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
title_short IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
title_full IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
title_fullStr IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
title_full_unstemmed IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
title_sort ibd risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c3282316b00248958032424db0e3a0c7
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