Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study

Abstract Knowledge of illicit drug users (IDUs) is important because of the comorbidity related to drug use. In this prospective, observational study, we screened 1007 patients undergoing emergency surgery and found that 75 of them (7.5%) were IDUs The results of preoperative screening showed that t...

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Autores principales:	Jingyi Li, He Ma, Ren Liao, Yanjuan Huang, Guiyong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c32c992124ab41a091a947edbedabb0f
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spelling	oai:doaj.org-article:c32c992124ab41a091a947edbedabb0f2021-12-02T11:41:03ZPreoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study10.1038/s41598-018-25829-32045-2322https://doaj.org/article/c32c992124ab41a091a947edbedabb0f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25829-3https://doaj.org/toc/2045-2322Abstract Knowledge of illicit drug users (IDUs) is important because of the comorbidity related to drug use. In this prospective, observational study, we screened 1007 patients undergoing emergency surgery and found that 75 of them (7.5%) were IDUs The results of preoperative screening showed that the rates of HIV and syphilis infection were significantly higher in IDUs (HIV (+) 2.6%, syphilis (+) 10.7%) than in non-IDUs (HIV (+) 0, syphilis (+) 0.5%). Intraoperative consumption of remifentanil (IDUs: 1.85 ± 1.30 vs. non-IDUs: 1.31 ± 0.86, p = 0.009), midazolam (IDUs: 4.82 ± 1.52 vs. non-IDUs: 4.15 ± 1.81, p = 0.002), and atracurium (IDUs: 31.5 ± 15.1 vs. non-IDUs: 25.5 ± 11.9, p = 0.006) and the proportion of patients requiring postoperative fentanyl (IDUs: 15 (20.0%) vs. non-IDUs: 95 (1.2%), p = 0.031) were significantly increased in IDUs compared to non-IDUs. Postoperative complications were observed in 22.7% (17/75) of patients who were IDUs, which was significantly increased when compared with non-IDUs (6.0%, 56/932, p < 0.001). The mortality rate within 30 days after surgery was similar between the two groups. These findings suggested that the IDUs were associated with increased rates of HIV and syphilis infection; greater consumption of intraoperative opioids, sedatives, and muscle relaxants; increased postoperative complications and a similar mortality rate within 30 days after surgery when compared with non-IDUs.Jingyi LiHe MaRen LiaoYanjuan HuangGuiyong ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingyi Li He Ma Ren Liao Yanjuan Huang Guiyong Chen Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
description	Abstract Knowledge of illicit drug users (IDUs) is important because of the comorbidity related to drug use. In this prospective, observational study, we screened 1007 patients undergoing emergency surgery and found that 75 of them (7.5%) were IDUs The results of preoperative screening showed that the rates of HIV and syphilis infection were significantly higher in IDUs (HIV (+) 2.6%, syphilis (+) 10.7%) than in non-IDUs (HIV (+) 0, syphilis (+) 0.5%). Intraoperative consumption of remifentanil (IDUs: 1.85 ± 1.30 vs. non-IDUs: 1.31 ± 0.86, p = 0.009), midazolam (IDUs: 4.82 ± 1.52 vs. non-IDUs: 4.15 ± 1.81, p = 0.002), and atracurium (IDUs: 31.5 ± 15.1 vs. non-IDUs: 25.5 ± 11.9, p = 0.006) and the proportion of patients requiring postoperative fentanyl (IDUs: 15 (20.0%) vs. non-IDUs: 95 (1.2%), p = 0.031) were significantly increased in IDUs compared to non-IDUs. Postoperative complications were observed in 22.7% (17/75) of patients who were IDUs, which was significantly increased when compared with non-IDUs (6.0%, 56/932, p < 0.001). The mortality rate within 30 days after surgery was similar between the two groups. These findings suggested that the IDUs were associated with increased rates of HIV and syphilis infection; greater consumption of intraoperative opioids, sedatives, and muscle relaxants; increased postoperative complications and a similar mortality rate within 30 days after surgery when compared with non-IDUs.
format	article
author	Jingyi Li He Ma Ren Liao Yanjuan Huang Guiyong Chen
author_facet	Jingyi Li He Ma Ren Liao Yanjuan Huang Guiyong Chen
author_sort	Jingyi Li
title	Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
title_short	Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
title_full	Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
title_fullStr	Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
title_full_unstemmed	Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study
title_sort	preoperative screening for illicit drug use in patients undergoing emergency surgery: a prospective observational study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c32c992124ab41a091a947edbedabb0f
work_keys_str_mv	AT jingyili preoperativescreeningforillicitdruguseinpatientsundergoingemergencysurgeryaprospectiveobservationalstudy AT hema preoperativescreeningforillicitdruguseinpatientsundergoingemergencysurgeryaprospectiveobservationalstudy AT renliao preoperativescreeningforillicitdruguseinpatientsundergoingemergencysurgeryaprospectiveobservationalstudy AT yanjuanhuang preoperativescreeningforillicitdruguseinpatientsundergoingemergencysurgeryaprospectiveobservationalstudy AT guiyongchen preoperativescreeningforillicitdruguseinpatientsundergoingemergencysurgeryaprospectiveobservationalstudy
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Preoperative screening for illicit drug use in patients undergoing emergency surgery: A prospective observational study

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