Novel fidaxomicin antibiotics through site-selective catalysis

Fidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moi...

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Autores principales:	David Dailler, Andrea Dorst, Daniel Schäfle, Peter Sander, Karl Gademann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c32e82beff5d448d939c9d14cc5a1314
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spelling	oai:doaj.org-article:c32e82beff5d448d939c9d14cc5a13142021-12-02T17:01:35ZNovel fidaxomicin antibiotics through site-selective catalysis10.1038/s42004-021-00501-62399-3669https://doaj.org/article/c32e82beff5d448d939c9d14cc5a13142021-05-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00501-6https://doaj.org/toc/2399-3669Fidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moieties.David DaillerAndrea DorstDaniel SchäflePeter SanderKarl GademannNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 David Dailler Andrea Dorst Daniel Schäfle Peter Sander Karl Gademann Novel fidaxomicin antibiotics through site-selective catalysis
description	Fidaxomicin is a narrow spectrum antibiotic, and broadening its activity through structural modification could provide new antibiotics. Here semi-synthetic derivatives are prepared through site-selective esterification and allylic substitution to efficiently modify or substitute key carbohydrate moieties.
format	article
author	David Dailler Andrea Dorst Daniel Schäfle Peter Sander Karl Gademann
author_facet	David Dailler Andrea Dorst Daniel Schäfle Peter Sander Karl Gademann
author_sort	David Dailler
title	Novel fidaxomicin antibiotics through site-selective catalysis
title_short	Novel fidaxomicin antibiotics through site-selective catalysis
title_full	Novel fidaxomicin antibiotics through site-selective catalysis
title_fullStr	Novel fidaxomicin antibiotics through site-selective catalysis
title_full_unstemmed	Novel fidaxomicin antibiotics through site-selective catalysis
title_sort	novel fidaxomicin antibiotics through site-selective catalysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c32e82beff5d448d939c9d14cc5a1314
work_keys_str_mv	AT daviddailler novelfidaxomicinantibioticsthroughsiteselectivecatalysis AT andreadorst novelfidaxomicinantibioticsthroughsiteselectivecatalysis AT danielschafle novelfidaxomicinantibioticsthroughsiteselectivecatalysis AT petersander novelfidaxomicinantibioticsthroughsiteselectivecatalysis AT karlgademann novelfidaxomicinantibioticsthroughsiteselectivecatalysis
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Novel fidaxomicin antibiotics through site-selective catalysis

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