Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease
Xue-Min Zhao, 1 Ping Zhuang, 1–3 Yong-jie Li, 1 Yu-qing Zhang, 1 Jian-yu Li, 1 Yun-peng Wang, 1 Ji-ping Li 1 1Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Center of Parkinson’s Disease...
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Dove Medical Press
2020
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oai:doaj.org-article:c33168e247cc4a72b1fb23721bef08cb2021-12-02T05:33:15ZAsymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease1178-2021https://doaj.org/article/c33168e247cc4a72b1fb23721bef08cb2020-01-01T00:00:00Zhttps://www.dovepress.com/asymmetry-of-subthalamic-neuronal-firing-rate-and-oscillatory-characte-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xue-Min Zhao, 1 Ping Zhuang, 1–3 Yong-jie Li, 1 Yu-qing Zhang, 1 Jian-yu Li, 1 Yun-peng Wang, 1 Ji-ping Li 1 1Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, People’s Republic of China; 3Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, Beijing, People’s Republic of ChinaCorrespondence: Ping ZhuangBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, People’s Republic of ChinaTel +86 10 83198887Fax +86 10 83199238Email zhuangping833@gmail.comPurpose: The aim of this study was to compare the neuronal firing rate and oscillatory activity of the subthalamic nucleus (STN) between the more affected (MA) and the less affected (LA) hemispheres in Parkinson’s disease (PD).Patients and Methods: We recorded and analyzed the intra-operative microelectrode recordings (MER) from the STN of 24 PD subjects. Lateralized Unified Parkinson’s Disease Rating Scale (UPDRS) III sub-scores (item 20– 26) were calculated. The STN corresponding to the MA side was designated as the MA STN while the other side as the LA STN. Single unit characteristics including interspike intervals were identified and spectral analyses were assessed. Further, the mean spontaneous firing rate (MSFR) of neurons was calculated. The correlations between clinical symptoms and neuronal activity were analyzed.Results: The firing rate in the MA and LA sides were 43.18 ± 0.74 Hz and 36.94 ± 1.32 Hz, respectively, with an increase of 16.9% in the MA group. The number of neurons that oscillated in the Tremor-Frequency Band (TFB), β-Frequency Band (βFB), and the non-oscillatory cells in the MA group were 43, 115, and 62 versus 78, 68, and 54 in the LA group, respectively. The proportions of the three types of neurons were different between both groups. The firing rate of the STN neurons and the UPDRS III sub-scores were positively correlated. Additionally, we observed a positive correlation between the percentage of βFB oscillatory neurons and bradykinesia score.Conclusion: The firing rate of the STN in the MA hemisphere is higher than in the LA side, following disease progression and there seems to be an increase in firing rate. The βFB oscillatory neurons are at a larger proportion in the MA group while there were larger percentage of TFB oscillatory cells in the LA group. The proportion of βFB oscillatory neurons is selectively correlated with the severity of bradykinesia.Keywords: Parkinson’s disease, subthalamic nucleus, intra-operative microelectrode recordings, tremor-frequency band, β-frequency band, βFBZhao XMZhuang PLi YZhang YLi JWang YLi JDove Medical Pressarticleparkinson’s diseasesubthalamic nucleusintra-operative microelectrode recordingstremor-frequency bandβ-frequency band (βfb)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 313-323 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
parkinson’s disease subthalamic nucleus intra-operative microelectrode recordings tremor-frequency band β-frequency band (βfb) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
parkinson’s disease subthalamic nucleus intra-operative microelectrode recordings tremor-frequency band β-frequency band (βfb) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhao XM Zhuang P Li Y Zhang Y Li J Wang Y Li J Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| description |
Xue-Min Zhao, 1 Ping Zhuang, 1–3 Yong-jie Li, 1 Yu-qing Zhang, 1 Jian-yu Li, 1 Yun-peng Wang, 1 Ji-ping Li 1 1Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, People’s Republic of China; 3Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, Beijing, People’s Republic of ChinaCorrespondence: Ping ZhuangBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, People’s Republic of ChinaTel +86 10 83198887Fax +86 10 83199238Email zhuangping833@gmail.comPurpose: The aim of this study was to compare the neuronal firing rate and oscillatory activity of the subthalamic nucleus (STN) between the more affected (MA) and the less affected (LA) hemispheres in Parkinson’s disease (PD).Patients and Methods: We recorded and analyzed the intra-operative microelectrode recordings (MER) from the STN of 24 PD subjects. Lateralized Unified Parkinson’s Disease Rating Scale (UPDRS) III sub-scores (item 20– 26) were calculated. The STN corresponding to the MA side was designated as the MA STN while the other side as the LA STN. Single unit characteristics including interspike intervals were identified and spectral analyses were assessed. Further, the mean spontaneous firing rate (MSFR) of neurons was calculated. The correlations between clinical symptoms and neuronal activity were analyzed.Results: The firing rate in the MA and LA sides were 43.18 ± 0.74 Hz and 36.94 ± 1.32 Hz, respectively, with an increase of 16.9% in the MA group. The number of neurons that oscillated in the Tremor-Frequency Band (TFB), β-Frequency Band (βFB), and the non-oscillatory cells in the MA group were 43, 115, and 62 versus 78, 68, and 54 in the LA group, respectively. The proportions of the three types of neurons were different between both groups. The firing rate of the STN neurons and the UPDRS III sub-scores were positively correlated. Additionally, we observed a positive correlation between the percentage of βFB oscillatory neurons and bradykinesia score.Conclusion: The firing rate of the STN in the MA hemisphere is higher than in the LA side, following disease progression and there seems to be an increase in firing rate. The βFB oscillatory neurons are at a larger proportion in the MA group while there were larger percentage of TFB oscillatory cells in the LA group. The proportion of βFB oscillatory neurons is selectively correlated with the severity of bradykinesia.Keywords: Parkinson’s disease, subthalamic nucleus, intra-operative microelectrode recordings, tremor-frequency band, β-frequency band, βFB |
| format |
article |
| author |
Zhao XM Zhuang P Li Y Zhang Y Li J Wang Y Li J |
| author_facet |
Zhao XM Zhuang P Li Y Zhang Y Li J Wang Y Li J |
| author_sort |
Zhao XM |
| title |
Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| title_short |
Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| title_full |
Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| title_fullStr |
Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| title_full_unstemmed |
Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease |
| title_sort |
asymmetry of subthalamic neuronal firing rate and oscillatory characteristics in parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/c33168e247cc4a72b1fb23721bef08cb |
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