Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

Here, the authors identify and characterize two mouse-derived monoclonal antibodies against SARS-CoV-2 spike protein that target different epitopes in RBD and block the interaction S/ACE2 and show that a formulated humanized version cocktail exhibits prophylaxis and therapeutic antiviral effects in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chao Zhang, Yifan Wang, Yuanfei Zhu, Caixuan Liu, Chenjian Gu, Shiqi Xu, Yalei Wang, Yu Zhou, Yanxing Wang, Wenyu Han, Xiaoyu Hong, Yong Yang, Xueyang Zhang, Tingfeng Wang, Cong Xu, Qin Hong, Shutian Wang, Qiaoyu Zhao, Weihua Qiao, Jinkai Zang, Liangliang Kong, Fangfang Wang, Haikun Wang, Di Qu, Dimitri Lavillette, Hong Tang, Qiang Deng, Youhua Xie, Yao Cong, Zhong Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c3382a0b06624f9aa3dc99ff11e7fed0
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c3382a0b06624f9aa3dc99ff11e7fed0
record_format dspace
spelling oai:doaj.org-article:c3382a0b06624f9aa3dc99ff11e7fed02021-12-02T14:12:04ZDevelopment and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections10.1038/s41467-020-20465-w2041-1723https://doaj.org/article/c3382a0b06624f9aa3dc99ff11e7fed02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20465-whttps://doaj.org/toc/2041-1723Here, the authors identify and characterize two mouse-derived monoclonal antibodies against SARS-CoV-2 spike protein that target different epitopes in RBD and block the interaction S/ACE2 and show that a formulated humanized version cocktail exhibits prophylaxis and therapeutic antiviral effects in an hACE2-adenovector expressed mouse model.Chao ZhangYifan WangYuanfei ZhuCaixuan LiuChenjian GuShiqi XuYalei WangYu ZhouYanxing WangWenyu HanXiaoyu HongYong YangXueyang ZhangTingfeng WangCong XuQin HongShutian WangQiaoyu ZhaoWeihua QiaoJinkai ZangLiangliang KongFangfang WangHaikun WangDi QuDimitri LavilletteHong TangQiang DengYouhua XieYao CongZhong HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chao Zhang
Yifan Wang
Yuanfei Zhu
Caixuan Liu
Chenjian Gu
Shiqi Xu
Yalei Wang
Yu Zhou
Yanxing Wang
Wenyu Han
Xiaoyu Hong
Yong Yang
Xueyang Zhang
Tingfeng Wang
Cong Xu
Qin Hong
Shutian Wang
Qiaoyu Zhao
Weihua Qiao
Jinkai Zang
Liangliang Kong
Fangfang Wang
Haikun Wang
Di Qu
Dimitri Lavillette
Hong Tang
Qiang Deng
Youhua Xie
Yao Cong
Zhong Huang
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
description Here, the authors identify and characterize two mouse-derived monoclonal antibodies against SARS-CoV-2 spike protein that target different epitopes in RBD and block the interaction S/ACE2 and show that a formulated humanized version cocktail exhibits prophylaxis and therapeutic antiviral effects in an hACE2-adenovector expressed mouse model.
format article
author Chao Zhang
Yifan Wang
Yuanfei Zhu
Caixuan Liu
Chenjian Gu
Shiqi Xu
Yalei Wang
Yu Zhou
Yanxing Wang
Wenyu Han
Xiaoyu Hong
Yong Yang
Xueyang Zhang
Tingfeng Wang
Cong Xu
Qin Hong
Shutian Wang
Qiaoyu Zhao
Weihua Qiao
Jinkai Zang
Liangliang Kong
Fangfang Wang
Haikun Wang
Di Qu
Dimitri Lavillette
Hong Tang
Qiang Deng
Youhua Xie
Yao Cong
Zhong Huang
author_facet Chao Zhang
Yifan Wang
Yuanfei Zhu
Caixuan Liu
Chenjian Gu
Shiqi Xu
Yalei Wang
Yu Zhou
Yanxing Wang
Wenyu Han
Xiaoyu Hong
Yong Yang
Xueyang Zhang
Tingfeng Wang
Cong Xu
Qin Hong
Shutian Wang
Qiaoyu Zhao
Weihua Qiao
Jinkai Zang
Liangliang Kong
Fangfang Wang
Haikun Wang
Di Qu
Dimitri Lavillette
Hong Tang
Qiang Deng
Youhua Xie
Yao Cong
Zhong Huang
author_sort Chao Zhang
title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
title_short Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
title_full Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
title_fullStr Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
title_full_unstemmed Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
title_sort development and structural basis of a two-mab cocktail for treating sars-cov-2 infections
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c3382a0b06624f9aa3dc99ff11e7fed0
work_keys_str_mv AT chaozhang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yifanwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yuanfeizhu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT caixuanliu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT chenjiangu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT shiqixu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yaleiwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yuzhou developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yanxingwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT wenyuhan developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT xiaoyuhong developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yongyang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT xueyangzhang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT tingfengwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT congxu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT qinhong developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT shutianwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT qiaoyuzhao developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT weihuaqiao developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT jinkaizang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT liangliangkong developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT fangfangwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT haikunwang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT diqu developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT dimitrilavillette developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT hongtang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT qiangdeng developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT youhuaxie developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT yaocong developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
AT zhonghuang developmentandstructuralbasisofatwomabcocktailfortreatingsarscov2infections
_version_ 1718391868259041280

Ejemplares similares