Systematic CRISPR-Cas9-Mediated Modifications of <italic toggle="yes">Plasmodium yoelii</italic> ApiAP2 Genes Reveal Functional Insights into Parasite Development

Systematic CRISPR-Cas9-Mediated Modifications of <italic toggle="yes">Plasmodium yoelii</italic> ApiAP2 Genes Reveal Functional Insights into Parasite Development

ABSTRACT Malaria parasites have a complex life cycle with multiple developmental stages in mosquito and vertebrate hosts, and different developmental stages express unique sets of genes. Unexpectedly, many transcription factors (TFs) commonly found in eukaryotic organisms are absent in malaria paras...

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Autores principales: Cui Zhang, Zhenkui Li, Huiting Cui, Yuanyuan Jiang, Zhenke Yang, Xu Wang, Han Gao, Cong Liu, Shujia Zhang, Xin-zhuan Su, Jing Yuan
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
genetic modification
malaria
mice
mosquito
transcription
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c3396187e2ae4c8c80ba3e40d5ba20f6
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