A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of...

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Autores principales:	Veronika V. Smirnova, Denis N. Chausov, Dmitriy A. Serov, Valery A. Kozlov, Petr I. Ivashkin, Roman Y. Pishchalnikov, Oleg V. Uvarov, Maria V. Vedunova, Anastasia A. Semenova, Andrey B. Lisitsyn, Alexander V. Simakin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanocomposite polymer material PLGA silver oxide nanoparticles reactive oxygen species bacteriostatic properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/c33b7d20e02e43b7ab6644357d7ca734
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spelling	oai:doaj.org-article:c33b7d20e02e43b7ab6644357d7ca7342021-11-25T18:14:41ZA Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells10.3390/ma142269151996-1944https://doaj.org/article/c33b7d20e02e43b7ab6644357d7ca7342021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6915https://doaj.org/toc/1996-1944A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.Veronika V. SmirnovaDenis N. ChausovDmitriy A. SerovValery A. KozlovPetr I. IvashkinRoman Y. PishchalnikovOleg V. UvarovMaria V. VedunovaAnastasia A. SemenovaAndrey B. LisitsynAlexander V. SimakinMDPI AGarticlenanocomposite polymer materialPLGAsilver oxide nanoparticlesreactive oxygen speciesbacteriostatic propertiesTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6915, p 6915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocomposite polymer material PLGA silver oxide nanoparticles reactive oxygen species bacteriostatic properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	nanocomposite polymer material PLGA silver oxide nanoparticles reactive oxygen species bacteriostatic properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
description	A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 10<sup>8</sup> nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.
format	article
author	Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin
author_facet	Veronika V. Smirnova Denis N. Chausov Dmitriy A. Serov Valery A. Kozlov Petr I. Ivashkin Roman Y. Pishchalnikov Oleg V. Uvarov Maria V. Vedunova Anastasia A. Semenova Andrey B. Lisitsyn Alexander V. Simakin
author_sort	Veronika V. Smirnova
title	A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
title_short	A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
title_full	A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
title_fullStr	A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
title_full_unstemmed	A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells
title_sort	novel biodegradable composite polymer material based on plga and silver oxide nanoparticles with unique physicochemical properties and biocompatibility with mammalian cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c33b7d20e02e43b7ab6644357d7ca734
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A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

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