The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice
A daily consumption of cranberry juice (CJ) is linked to many beneficial health effects due to its richness in polyphenols but could also awake some intestinal discomforts due to its organic acid content and possibly lead to intestinal inflammation. Additionally, the impact of such a juice on the gu...
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2021
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oai:doaj.org-article:c3440db7e5fa442cade85883c4ba967c2021-11-11T16:59:55ZThe Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice10.3390/ijms2221115371422-00671661-6596https://doaj.org/article/c3440db7e5fa442cade85883c4ba967c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11537https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067A daily consumption of cranberry juice (CJ) is linked to many beneficial health effects due to its richness in polyphenols but could also awake some intestinal discomforts due to its organic acid content and possibly lead to intestinal inflammation. Additionally, the impact of such a juice on the gut microbiota is still unknown. Thus, this study aimed to determine the impacts of a daily consumption of CJ and its successive deacidification on the intestinal inflammation and on the gut microbiota in mice. Four deacidified CJs (DCJs) (deacidification rates of 0, 40, 60, and 80%) were produced by electrodialysis with bipolar membrane (EDBM) and administered to C57BL/6J mice for four weeks, while the diet (CHOW) and the water were <i>ad libitum</i>. Different parameters were measured to determine intestinal inflammation when the gut microbiota was profiled. Treatment with a 0% DCJ did not induce intestinal inflammation but increased the gut microbiota diversity and induced a modulation of its functions in comparison with control (water). The effect of the removal of the organic acid content of CJ on the decrease of intestinal inflammation could not be observed. However, deacidification by EDBM of CJ induced an additional increase, in comparison with a 0% DCJ, in the <i>Lachnospiraceae</i> family which have beneficial effects and functions associated with protection of the intestine: the lower the organic acid content, the more bacteria of the <i>Lachnospiraceae</i> family and functions having a positive impact on the gut microbiota.Valentine RenaudVanessa P. HoudeGeneviève PilonThibault V. VarinCyril RobletAndré MaretteYvan BoutinLaurent BazinetMDPI AGarticlecranberry juicepolyphenolsorganic acidsorganic acid removalelectrodialysis with bipolar membranemice modelBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11537, p 11537 (2021) |
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EN |
| topic |
cranberry juice polyphenols organic acids organic acid removal electrodialysis with bipolar membrane mice model Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
cranberry juice polyphenols organic acids organic acid removal electrodialysis with bipolar membrane mice model Biology (General) QH301-705.5 Chemistry QD1-999 Valentine Renaud Vanessa P. Houde Geneviève Pilon Thibault V. Varin Cyril Roblet André Marette Yvan Boutin Laurent Bazinet The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| description |
A daily consumption of cranberry juice (CJ) is linked to many beneficial health effects due to its richness in polyphenols but could also awake some intestinal discomforts due to its organic acid content and possibly lead to intestinal inflammation. Additionally, the impact of such a juice on the gut microbiota is still unknown. Thus, this study aimed to determine the impacts of a daily consumption of CJ and its successive deacidification on the intestinal inflammation and on the gut microbiota in mice. Four deacidified CJs (DCJs) (deacidification rates of 0, 40, 60, and 80%) were produced by electrodialysis with bipolar membrane (EDBM) and administered to C57BL/6J mice for four weeks, while the diet (CHOW) and the water were <i>ad libitum</i>. Different parameters were measured to determine intestinal inflammation when the gut microbiota was profiled. Treatment with a 0% DCJ did not induce intestinal inflammation but increased the gut microbiota diversity and induced a modulation of its functions in comparison with control (water). The effect of the removal of the organic acid content of CJ on the decrease of intestinal inflammation could not be observed. However, deacidification by EDBM of CJ induced an additional increase, in comparison with a 0% DCJ, in the <i>Lachnospiraceae</i> family which have beneficial effects and functions associated with protection of the intestine: the lower the organic acid content, the more bacteria of the <i>Lachnospiraceae</i> family and functions having a positive impact on the gut microbiota. |
| format |
article |
| author |
Valentine Renaud Vanessa P. Houde Geneviève Pilon Thibault V. Varin Cyril Roblet André Marette Yvan Boutin Laurent Bazinet |
| author_facet |
Valentine Renaud Vanessa P. Houde Geneviève Pilon Thibault V. Varin Cyril Roblet André Marette Yvan Boutin Laurent Bazinet |
| author_sort |
Valentine Renaud |
| title |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| title_short |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| title_full |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| title_fullStr |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| title_full_unstemmed |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice |
| title_sort |
concentration of organic acids in cranberry juice modulates the gut microbiota in mice |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c3440db7e5fa442cade85883c4ba967c |
| work_keys_str_mv |
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