Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study

Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used i...

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Autores principales:	Farhad Handjani, Shahin Aghaei, Iman Moezzi, Nasrin Saki
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2017
Materias:	vitiligo mycophenolate mofetil repigmentation Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/c346a1a33b2b476299bc64e2f48e302e
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spelling	oai:doaj.org-article:c346a1a33b2b476299bc64e2f48e302e2021-11-17T08:30:49ZTopical mycophenolate mofetil in the treatment of vitiligo: a pilot study10.5826/dpc.0702a062160-9381https://doaj.org/article/c346a1a33b2b476299bc64e2f48e302e2017-05-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/221https://doaj.org/toc/2160-9381 Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis. Objectives: The objective of this study was to show the efficacy of topical mycophenolate mofetil in the treatment of vitiligo. Methods: Thirty patients with limited vitiligo were enrolled in this study. The patients applied a topical preparation of mycophenolate mofetil 15% twice daily for three months and at the end of every month, repigmentation was assessed using the Vitiligo Area Scoring Index (VASI). Results: At the end of the third month, 36.6 % (n=11) of the patients showed about 25% repigmentation of the lesions. No side effects were observed throughout the study. Conclusion: This study showed that topical mycophenolate mofetil can be somewhat effective in the treatment of vitiligo; however, it seems to be inferior to potent topical steroids in inducing repigmentation. Farhad HandjaniShahin AghaeiIman MoezziNasrin SakiMattioli1885articlevitiligomycophenolate mofetilrepigmentationDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 7, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitiligo mycophenolate mofetil repigmentation Dermatology RL1-803
spellingShingle	vitiligo mycophenolate mofetil repigmentation Dermatology RL1-803 Farhad Handjani Shahin Aghaei Iman Moezzi Nasrin Saki Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
description	Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis. Objectives: The objective of this study was to show the efficacy of topical mycophenolate mofetil in the treatment of vitiligo. Methods: Thirty patients with limited vitiligo were enrolled in this study. The patients applied a topical preparation of mycophenolate mofetil 15% twice daily for three months and at the end of every month, repigmentation was assessed using the Vitiligo Area Scoring Index (VASI). Results: At the end of the third month, 36.6 % (n=11) of the patients showed about 25% repigmentation of the lesions. No side effects were observed throughout the study. Conclusion: This study showed that topical mycophenolate mofetil can be somewhat effective in the treatment of vitiligo; however, it seems to be inferior to potent topical steroids in inducing repigmentation.
format	article
author	Farhad Handjani Shahin Aghaei Iman Moezzi Nasrin Saki
author_facet	Farhad Handjani Shahin Aghaei Iman Moezzi Nasrin Saki
author_sort	Farhad Handjani
title	Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
title_short	Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
title_full	Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
title_fullStr	Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
title_full_unstemmed	Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
title_sort	topical mycophenolate mofetil in the treatment of vitiligo: a pilot study
publisher	Mattioli1885
publishDate	2017
url	https://doaj.org/article/c346a1a33b2b476299bc64e2f48e302e
work_keys_str_mv	AT farhadhandjani topicalmycophenolatemofetilinthetreatmentofvitiligoapilotstudy AT shahinaghaei topicalmycophenolatemofetilinthetreatmentofvitiligoapilotstudy AT imanmoezzi topicalmycophenolatemofetilinthetreatmentofvitiligoapilotstudy AT nasrinsaki topicalmycophenolatemofetilinthetreatmentofvitiligoapilotstudy
_version_	1718425763504455680

Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study

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