Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model
Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative hea...
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2021
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oai:doaj.org-article:c34a3bb73fb343839f4c29669871c89e2021-11-25T18:34:46ZDoes Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model10.3390/nu131138652072-6643https://doaj.org/article/c34a3bb73fb343839f4c29669871c89e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3865https://doaj.org/toc/2072-6643Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the <i>Lachnospiraceae</i> family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles.Maxence JolletKevin NayAngèle ChopardMarie-Pierre BareilleArnaud BeckVincent OllendorffBarbara VernusAnne BonnieuMahendra MariadassouOlivier RuéFrédéric DerbréBénédicte GoustardChristelle Koechlin-RamonatxoMDPI AGarticlehypoactivitycommensal bacteriafloraphylamuscle atrophydisuseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3865, p 3865 (2021) |
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hypoactivity commensal bacteria flora phyla muscle atrophy disuse Nutrition. Foods and food supply TX341-641 |
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hypoactivity commensal bacteria flora phyla muscle atrophy disuse Nutrition. Foods and food supply TX341-641 Maxence Jollet Kevin Nay Angèle Chopard Marie-Pierre Bareille Arnaud Beck Vincent Ollendorff Barbara Vernus Anne Bonnieu Mahendra Mariadassou Olivier Rué Frédéric Derbré Bénédicte Goustard Christelle Koechlin-Ramonatxo Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| description |
Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the <i>Lachnospiraceae</i> family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles. |
| format |
article |
| author |
Maxence Jollet Kevin Nay Angèle Chopard Marie-Pierre Bareille Arnaud Beck Vincent Ollendorff Barbara Vernus Anne Bonnieu Mahendra Mariadassou Olivier Rué Frédéric Derbré Bénédicte Goustard Christelle Koechlin-Ramonatxo |
| author_facet |
Maxence Jollet Kevin Nay Angèle Chopard Marie-Pierre Bareille Arnaud Beck Vincent Ollendorff Barbara Vernus Anne Bonnieu Mahendra Mariadassou Olivier Rué Frédéric Derbré Bénédicte Goustard Christelle Koechlin-Ramonatxo |
| author_sort |
Maxence Jollet |
| title |
Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| title_short |
Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| title_full |
Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| title_fullStr |
Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| title_full_unstemmed |
Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model |
| title_sort |
does physical inactivity induce significant changes in human gut microbiota? new answers using the dry immersion hypoactivity model |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c34a3bb73fb343839f4c29669871c89e |
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