Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the ami...

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Bibliographic Details
Main Authors: Erik Engelen, Roel C Janssens, Kazuhiro Yagita, Veronique A J Smits, Gijsbertus T J van der Horst, Filippo Tamanini
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c3526d46ec8d42e2a4920d56d7cdf7dd
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