Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the ami...

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Auteurs principaux: Erik Engelen, Roel C Janssens, Kazuhiro Yagita, Veronique A J Smits, Gijsbertus T J van der Horst, Filippo Tamanini
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
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Accès en ligne:https://doaj.org/article/c3526d46ec8d42e2a4920d56d7cdf7dd
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