MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

Bloom helicase is recruited to double strand breaks in an ATM dependent manner. Here the authors show that Bloom helicase is recruited to double strand breaks in an ATM and MRN dependent manner with HR and NHEJ regulated by the helicase depending on the phase of the cell cycle.

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Autores principales:	Vivek Tripathi, Himanshi Agarwal, Swati Priya, Harish Batra, Priyanka Modi, Monica Pandey, Dhurjhoti Saha, Sathees C. Raghavan, Sagar Sengupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3555540331742b480d02601fab3415b
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spelling	oai:doaj.org-article:c3555540331742b480d02601fab3415b2021-12-02T14:41:28ZMRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways10.1038/s41467-018-03393-82041-1723https://doaj.org/article/c3555540331742b480d02601fab3415b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03393-8https://doaj.org/toc/2041-1723Bloom helicase is recruited to double strand breaks in an ATM dependent manner. Here the authors show that Bloom helicase is recruited to double strand breaks in an ATM and MRN dependent manner with HR and NHEJ regulated by the helicase depending on the phase of the cell cycle.Vivek TripathiHimanshi AgarwalSwati PriyaHarish BatraPriyanka ModiMonica PandeyDhurjhoti SahaSathees C. RaghavanSagar SenguptaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vivek Tripathi Himanshi Agarwal Swati Priya Harish Batra Priyanka Modi Monica Pandey Dhurjhoti Saha Sathees C. Raghavan Sagar Sengupta MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
description	Bloom helicase is recruited to double strand breaks in an ATM dependent manner. Here the authors show that Bloom helicase is recruited to double strand breaks in an ATM and MRN dependent manner with HR and NHEJ regulated by the helicase depending on the phase of the cell cycle.
format	article
author	Vivek Tripathi Himanshi Agarwal Swati Priya Harish Batra Priyanka Modi Monica Pandey Dhurjhoti Saha Sathees C. Raghavan Sagar Sengupta
author_facet	Vivek Tripathi Himanshi Agarwal Swati Priya Harish Batra Priyanka Modi Monica Pandey Dhurjhoti Saha Sathees C. Raghavan Sagar Sengupta
author_sort	Vivek Tripathi
title	MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
title_short	MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
title_full	MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
title_fullStr	MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
title_full_unstemmed	MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
title_sort	mrn complex-dependent recruitment of ubiquitylated blm helicase to dsbs negatively regulates dna repair pathways
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c3555540331742b480d02601fab3415b
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MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

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