Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering

Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering

Abstract The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility. PDZD8 is an ER transmembrane protein containing a Synaptotagmin-like Mitochondrial lipid-binding Proteins (SMP) domain. PDZD8 teth...

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Autores principales: Haider Khan, Lin Chen, Lingchen Tan, Young Jun Im
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/c356627450f1438195c4b1d42f67f384
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