Regulators of pluripotency and their implications in regenerative medicine

Ahmed El-Badawy, Nagwa El-Badri Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Giza, Egypt Abstract: The ultimate goal of regenerative medicine is to replace damaged tissues with new functioning ones. This can potentially be accomplished by ste...

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Autores principales:	El-Badawy A, El-Badri N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/c356fb8f37014f7cbb285e7c590982df
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spelling	oai:doaj.org-article:c356fb8f37014f7cbb285e7c590982df2021-12-02T03:41:11ZRegulators of pluripotency and their implications in regenerative medicine1178-6957https://doaj.org/article/c356fb8f37014f7cbb285e7c590982df2015-04-01T00:00:00Zhttp://www.dovepress.com/regulators-of-pluripotency-and-their-implications-in-regenerative-medi-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Ahmed El-Badawy, Nagwa El-Badri Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Giza, Egypt Abstract: The ultimate goal of regenerative medicine is to replace damaged tissues with new functioning ones. This can potentially be accomplished by stem cell transplantation. While stem cell transplantation for blood diseases has been increasingly successful, widespread application of stem cell therapy in the clinic has shown limited results. Despite successful efforts to refine existing methodologies and to develop better ones for reprogramming, clinical application of stem cell therapy suffers from issues related to the safety of the transplanted cells, as well as the low efficiency of reprogramming technology. Better understanding of the underlying mechanism(s) involved in pluripotency should accelerate the clinical application of stem cell transplantation for regenerative purposes. This review outlines the main decision-making factors involved in pluripotency, focusing on the role of microRNAs, epigenetic modification, signaling pathways, and toll-like receptors. Of special interest is the role of toll-like receptors in pluripotency, where emerging data indicate that the innate immune system plays a vital role in reprogramming. Based on these data, we propose that nongenetic mechanisms for reprogramming provide a novel and perhaps an essential strategy to accelerate application of regenerative medicine in the clinic. Keywords: dedifferentiation, transdifferentiation, reprogramming, pluripotency, microRNAs, epigenetic modifications, signaling pathways, toll-like receptorsEl-Badawy AEl-Badri NDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 67-80 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 El-Badawy A El-Badri N Regulators of pluripotency and their implications in regenerative medicine
description	Ahmed El-Badawy, Nagwa El-Badri Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Giza, Egypt Abstract: The ultimate goal of regenerative medicine is to replace damaged tissues with new functioning ones. This can potentially be accomplished by stem cell transplantation. While stem cell transplantation for blood diseases has been increasingly successful, widespread application of stem cell therapy in the clinic has shown limited results. Despite successful efforts to refine existing methodologies and to develop better ones for reprogramming, clinical application of stem cell therapy suffers from issues related to the safety of the transplanted cells, as well as the low efficiency of reprogramming technology. Better understanding of the underlying mechanism(s) involved in pluripotency should accelerate the clinical application of stem cell transplantation for regenerative purposes. This review outlines the main decision-making factors involved in pluripotency, focusing on the role of microRNAs, epigenetic modification, signaling pathways, and toll-like receptors. Of special interest is the role of toll-like receptors in pluripotency, where emerging data indicate that the innate immune system plays a vital role in reprogramming. Based on these data, we propose that nongenetic mechanisms for reprogramming provide a novel and perhaps an essential strategy to accelerate application of regenerative medicine in the clinic. Keywords: dedifferentiation, transdifferentiation, reprogramming, pluripotency, microRNAs, epigenetic modifications, signaling pathways, toll-like receptors
format	article
author	El-Badawy A El-Badri N
author_facet	El-Badawy A El-Badri N
author_sort	El-Badawy A
title	Regulators of pluripotency and their implications in regenerative medicine
title_short	Regulators of pluripotency and their implications in regenerative medicine
title_full	Regulators of pluripotency and their implications in regenerative medicine
title_fullStr	Regulators of pluripotency and their implications in regenerative medicine
title_full_unstemmed	Regulators of pluripotency and their implications in regenerative medicine
title_sort	regulators of pluripotency and their implications in regenerative medicine
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c356fb8f37014f7cbb285e7c590982df
work_keys_str_mv	AT elbadawya regulatorsofpluripotencyandtheirimplicationsinregenerativemedicine AT elbadrin regulatorsofpluripotencyandtheirimplicationsinregenerativemedicine
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Regulators of pluripotency and their implications in regenerative medicine

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