Cerium oxide nanoparticles: green synthesis and biological applications
Fahimeh Charbgoo,1 Mansor Bin Ahmad,2,* Majid Darroudi3,* 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Nuclear Medicine R...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2017
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| Acceso en línea: | https://doaj.org/article/c358412786fd428192ed4fa60a428e36 |
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| Sumario: | Fahimeh Charbgoo,1 Mansor Bin Ahmad,2,* Majid Darroudi3,* 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran *These authors contributed equally to this work Abstract: CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO2-NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO2-NPs in biological and medical fields. Exploiting biocompatible CeO2-NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology. Keywords: cerium oxide nanoparticles, green synthesis, biocompatibility, surface Ce3+, size, morphology |
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