Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year

Abstract To investigate the visual/anatomical outcome of diabetic macular edema (DME) patients lost to follow-up (LTFU) for more than 1 year during intravitreal anti-VEGF treatment. A retrospective review of 182 treatment-naïve DME patients was performed. Among them, we identified patients LTFU for...

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Autores principales:	Ji Soo Kim, Seungheon Lee, Jin Young Kim, Eoi Jong Seo, Ju Byung Chae, Dong Yoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3596b1ee61e4b748b23d758f9e99aa8
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spelling	oai:doaj.org-article:c3596b1ee61e4b748b23d758f9e99aa82021-12-02T18:33:46ZVisual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year10.1038/s41598-021-97644-22045-2322https://doaj.org/article/c3596b1ee61e4b748b23d758f9e99aa82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97644-2https://doaj.org/toc/2045-2322Abstract To investigate the visual/anatomical outcome of diabetic macular edema (DME) patients lost to follow-up (LTFU) for more than 1 year during intravitreal anti-VEGF treatment. A retrospective review of 182 treatment-naïve DME patients was performed. Among them, we identified patients LTFU for more than 1 year during anti-VEGF treatment. Visual acuity and anatomic outcomes at the first visit, last visit before being LTFU, return visit, and after re-treatment were analyzed and compared with those of DME patients with regular follow-up. Patients who had continuous follow-up visits were assigned to the control group. Sixty patients (33%) with DME were LTFU for more than 1 year during anti-VEGF treatment. Multivariate analysis revealed that the ratio of male (p = 0.004), diabetes mellitus (DM) duration less than 5 years (p = 0.015), and poor early anatomic response (p = 0.012) were higher compared to the control group. Eighteen patients returned to the clinic and received re-treatment. After re-treatment with anti-VEGF, central subfield thickness (CST) was significantly improved to the CST of before LTFU. However, visual acuity did not recover to the level before LTFU (0.63 ± 0.26 vs. 0.45 ± 0.28, p = 0.003). About thirty percent of DME patients were LTFU for more than 1 year. Permanent visual loss was observed in these LTFU patients. Patients with a high risk of LTFU such as male, early DM, and poor response after initial injections should be treated more aggressively to improve the visual outcomes.Ji Soo KimSeungheon LeeJin Young KimEoi Jong SeoJu Byung ChaeDong Yoon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Soo Kim Seungheon Lee Jin Young Kim Eoi Jong Seo Ju Byung Chae Dong Yoon Kim Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
description	Abstract To investigate the visual/anatomical outcome of diabetic macular edema (DME) patients lost to follow-up (LTFU) for more than 1 year during intravitreal anti-VEGF treatment. A retrospective review of 182 treatment-naïve DME patients was performed. Among them, we identified patients LTFU for more than 1 year during anti-VEGF treatment. Visual acuity and anatomic outcomes at the first visit, last visit before being LTFU, return visit, and after re-treatment were analyzed and compared with those of DME patients with regular follow-up. Patients who had continuous follow-up visits were assigned to the control group. Sixty patients (33%) with DME were LTFU for more than 1 year during anti-VEGF treatment. Multivariate analysis revealed that the ratio of male (p = 0.004), diabetes mellitus (DM) duration less than 5 years (p = 0.015), and poor early anatomic response (p = 0.012) were higher compared to the control group. Eighteen patients returned to the clinic and received re-treatment. After re-treatment with anti-VEGF, central subfield thickness (CST) was significantly improved to the CST of before LTFU. However, visual acuity did not recover to the level before LTFU (0.63 ± 0.26 vs. 0.45 ± 0.28, p = 0.003). About thirty percent of DME patients were LTFU for more than 1 year. Permanent visual loss was observed in these LTFU patients. Patients with a high risk of LTFU such as male, early DM, and poor response after initial injections should be treated more aggressively to improve the visual outcomes.
format	article
author	Ji Soo Kim Seungheon Lee Jin Young Kim Eoi Jong Seo Ju Byung Chae Dong Yoon Kim
author_facet	Ji Soo Kim Seungheon Lee Jin Young Kim Eoi Jong Seo Ju Byung Chae Dong Yoon Kim
author_sort	Ji Soo Kim
title	Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
title_short	Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
title_full	Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
title_fullStr	Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
title_full_unstemmed	Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
title_sort	visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3596b1ee61e4b748b23d758f9e99aa8
work_keys_str_mv	AT jisookim visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year AT seungheonlee visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year AT jinyoungkim visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year AT eoijongseo visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year AT jubyungchae visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year AT dongyoonkim visualanatomicaloutcomeofdiabeticmacularedemapatientslosttofollowupformorethan1year
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Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year

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