Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction

Abstract Neutrophil extracellular traps (NETs) which have a potential role in noninfectious diseases, may play an important role in patients with acute coronary syndrome. The goal of this study was to investigate the association of NETs and in-hospital major adverse cardiac events among patients wit...

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Autores principales:	Jing Liu, Dandan Yang, Xiqiang Wang, Zhonghai Zhu, Tingzhong Wang, Aiqun Ma, Ping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c35bd4defdcc456e980936dd2ee40fef
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spelling	oai:doaj.org-article:c35bd4defdcc456e980936dd2ee40fef2021-12-02T16:08:04ZNeutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction10.1038/s41598-019-47853-72045-2322https://doaj.org/article/c35bd4defdcc456e980936dd2ee40fef2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47853-7https://doaj.org/toc/2045-2322Abstract Neutrophil extracellular traps (NETs) which have a potential role in noninfectious diseases, may play an important role in patients with acute coronary syndrome. The goal of this study was to investigate the association of NETs and in-hospital major adverse cardiac events among patients with ST-segment elevation myocardial infarction (STEMI). Using immunofluorescence staining, ELISA, and fluorescent enzyme standard instrument, we assessed NETs and NETs-related factors. Multivariate analyses were performed after univariate analyses to investigate which variables were independently associated with major adverse cardiac events. Compared with peripheral arteries, we observed neutrophils obtained from infarct-related artery (IRA) releasing NETs. The dsDNA levels, NET-specific marker myeloperoxidase/deoxyribonucleic acid (MPO/DNA) complexes and NETs-related factor tissue factor were significantly higher in coronary plasma samples. Multivariate analysis that white cell counts and coronary dsDNA were independently associated with in-hospital major adverse cardiac events. ROC curve for coronary dsDNA showed sensitivity of 78.0% and specificity of 53% for the cut-off value of 0.39ug/ml. Conclusion, these results provide evidences indicating NETs were associated with STIM, and occurrence of adverse cardiac events.Jing LiuDandan YangXiqiang WangZhonghai ZhuTingzhong WangAiqun MaPing LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Liu Dandan Yang Xiqiang Wang Zhonghai Zhu Tingzhong Wang Aiqun Ma Ping Liu Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
description	Abstract Neutrophil extracellular traps (NETs) which have a potential role in noninfectious diseases, may play an important role in patients with acute coronary syndrome. The goal of this study was to investigate the association of NETs and in-hospital major adverse cardiac events among patients with ST-segment elevation myocardial infarction (STEMI). Using immunofluorescence staining, ELISA, and fluorescent enzyme standard instrument, we assessed NETs and NETs-related factors. Multivariate analyses were performed after univariate analyses to investigate which variables were independently associated with major adverse cardiac events. Compared with peripheral arteries, we observed neutrophils obtained from infarct-related artery (IRA) releasing NETs. The dsDNA levels, NET-specific marker myeloperoxidase/deoxyribonucleic acid (MPO/DNA) complexes and NETs-related factor tissue factor were significantly higher in coronary plasma samples. Multivariate analysis that white cell counts and coronary dsDNA were independently associated with in-hospital major adverse cardiac events. ROC curve for coronary dsDNA showed sensitivity of 78.0% and specificity of 53% for the cut-off value of 0.39ug/ml. Conclusion, these results provide evidences indicating NETs were associated with STIM, and occurrence of adverse cardiac events.
format	article
author	Jing Liu Dandan Yang Xiqiang Wang Zhonghai Zhu Tingzhong Wang Aiqun Ma Ping Liu
author_facet	Jing Liu Dandan Yang Xiqiang Wang Zhonghai Zhu Tingzhong Wang Aiqun Ma Ping Liu
author_sort	Jing Liu
title	Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
title_short	Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
title_full	Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
title_fullStr	Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
title_full_unstemmed	Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction
title_sort	neutrophil extracellular traps and dsdna predict outcomes among patients with st-elevation myocardial infarction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c35bd4defdcc456e980936dd2ee40fef
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Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction

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