Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities

Abstract The interaction between the thalamus and sensory cortex plays critical roles in sensory processing. Previous studies have revealed pathway-specific synaptic properties of thalamo-cortical connections. However, few studies to date have investigated how each pathway routes moment-to-moment in...

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Autores principales:	Kotaro Ishizu, Tomoyo I. Shiramatsu, Rie Hitsuyu, Masafumi Oizumi, Naotsugu Tsuchiya, Hirokazu Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c361e0eeab1847f595afec51d95b7811
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spelling	oai:doaj.org-article:c361e0eeab1847f595afec51d95b78112021-12-02T17:37:34ZInformation flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities10.1038/s41598-021-98660-y2045-2322https://doaj.org/article/c361e0eeab1847f595afec51d95b78112021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98660-yhttps://doaj.org/toc/2045-2322Abstract The interaction between the thalamus and sensory cortex plays critical roles in sensory processing. Previous studies have revealed pathway-specific synaptic properties of thalamo-cortical connections. However, few studies to date have investigated how each pathway routes moment-to-moment information. Here, we simultaneously recorded neural activity in the auditory thalamus (or ventral division of the medial geniculate body; MGv) and primary auditory cortex (A1) with a laminar resolution in anesthetized rats. Transfer entropy (TE) was used as an information theoretic measure to operationalize “information flow”. Our analyses confirmed that communication between the thalamus and cortex was strengthened during presentation of auditory stimuli. In the resting state, thalamo-cortical communications almost disappeared, whereas intracortical communications were strengthened. The predominant source of information was the MGv at the onset of stimulus presentation and layer 5 during spontaneous activity. In turn, MGv was the major recipient of information from layer 6. TE suggested that a small but significant population of MGv-to-A1 pairs was “information-bearing,” whereas A1-to-MGv pairs typically exhibiting small effects played modulatory roles. These results highlight the capability of TE analyses to unlock novel avenues for bridging the gap between well-established anatomical knowledge of canonical microcircuits and physiological correlates via the concept of dynamic information flow.Kotaro IshizuTomoyo I. ShiramatsuRie HitsuyuMasafumi OizumiNaotsugu TsuchiyaHirokazu TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kotaro Ishizu Tomoyo I. Shiramatsu Rie Hitsuyu Masafumi Oizumi Naotsugu Tsuchiya Hirokazu Takahashi Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
description	Abstract The interaction between the thalamus and sensory cortex plays critical roles in sensory processing. Previous studies have revealed pathway-specific synaptic properties of thalamo-cortical connections. However, few studies to date have investigated how each pathway routes moment-to-moment information. Here, we simultaneously recorded neural activity in the auditory thalamus (or ventral division of the medial geniculate body; MGv) and primary auditory cortex (A1) with a laminar resolution in anesthetized rats. Transfer entropy (TE) was used as an information theoretic measure to operationalize “information flow”. Our analyses confirmed that communication between the thalamus and cortex was strengthened during presentation of auditory stimuli. In the resting state, thalamo-cortical communications almost disappeared, whereas intracortical communications were strengthened. The predominant source of information was the MGv at the onset of stimulus presentation and layer 5 during spontaneous activity. In turn, MGv was the major recipient of information from layer 6. TE suggested that a small but significant population of MGv-to-A1 pairs was “information-bearing,” whereas A1-to-MGv pairs typically exhibiting small effects played modulatory roles. These results highlight the capability of TE analyses to unlock novel avenues for bridging the gap between well-established anatomical knowledge of canonical microcircuits and physiological correlates via the concept of dynamic information flow.
format	article
author	Kotaro Ishizu Tomoyo I. Shiramatsu Rie Hitsuyu Masafumi Oizumi Naotsugu Tsuchiya Hirokazu Takahashi
author_facet	Kotaro Ishizu Tomoyo I. Shiramatsu Rie Hitsuyu Masafumi Oizumi Naotsugu Tsuchiya Hirokazu Takahashi
author_sort	Kotaro Ishizu
title	Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
title_short	Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
title_full	Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
title_fullStr	Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
title_full_unstemmed	Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
title_sort	information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c361e0eeab1847f595afec51d95b7811
work_keys_str_mv	AT kotaroishizu informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities AT tomoyoishiramatsu informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities AT riehitsuyu informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities AT masafumioizumi informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities AT naotsugutsuchiya informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities AT hirokazutakahashi informationflowintheratthalamocorticalsystemspontaneousvsstimulusevokedactivities
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Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities

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