Extinct type of human parvovirus B19 persists in tonsillar B cells

The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent.

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Autores principales:	Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman, Maria F. Perdomo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c361ff35670e4ffbbdd991ab4dfb34ac
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spelling	oai:doaj.org-article:c361ff35670e4ffbbdd991ab4dfb34ac2021-12-02T15:37:03ZExtinct type of human parvovirus B19 persists in tonsillar B cells10.1038/ncomms149302041-1723https://doaj.org/article/c361ff35670e4ffbbdd991ab4dfb34ac2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14930https://doaj.org/toc/2041-1723The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent.Lari PyöriäMari ToppinenElina MäntyläLea HedmanLeena-Maija AaltonenMaija Vihinen-RantaTaru IlmarinenMaria Söderlund-VenermoKlaus HedmanMaria F. PerdomoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lari Pyöriä Mari Toppinen Elina Mäntylä Lea Hedman Leena-Maija Aaltonen Maija Vihinen-Ranta Taru Ilmarinen Maria Söderlund-Venermo Klaus Hedman Maria F. Perdomo Extinct type of human parvovirus B19 persists in tonsillar B cells
description	The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent.
format	article
author	Lari Pyöriä Mari Toppinen Elina Mäntylä Lea Hedman Leena-Maija Aaltonen Maija Vihinen-Ranta Taru Ilmarinen Maria Söderlund-Venermo Klaus Hedman Maria F. Perdomo
author_facet	Lari Pyöriä Mari Toppinen Elina Mäntylä Lea Hedman Leena-Maija Aaltonen Maija Vihinen-Ranta Taru Ilmarinen Maria Söderlund-Venermo Klaus Hedman Maria F. Perdomo
author_sort	Lari Pyöriä
title	Extinct type of human parvovirus B19 persists in tonsillar B cells
title_short	Extinct type of human parvovirus B19 persists in tonsillar B cells
title_full	Extinct type of human parvovirus B19 persists in tonsillar B cells
title_fullStr	Extinct type of human parvovirus B19 persists in tonsillar B cells
title_full_unstemmed	Extinct type of human parvovirus B19 persists in tonsillar B cells
title_sort	extinct type of human parvovirus b19 persists in tonsillar b cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c361ff35670e4ffbbdd991ab4dfb34ac
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_version_	1718386256549773312

Extinct type of human parvovirus B19 persists in tonsillar B cells

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