Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells

Abstract Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown. Ou...

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Autores principales:	Sebastian Lunemann, Gloria Martrus, Hanna Goebels, Tobias Kautz, Annika Langeneckert, Wilhelm Salzberger, Martina Koch, Madeleine J. Bunders, Björn Nashan, Klaas P. J. M. van Gisbergen, Marcus Altfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c362062aeb504ceeb4c42b5b0788dc16
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spelling	oai:doaj.org-article:c362062aeb504ceeb4c42b5b0788dc162021-12-02T11:53:08ZHobit expression by a subset of human liver-resident CD56bright Natural Killer cells10.1038/s41598-017-06011-72045-2322https://doaj.org/article/c362062aeb504ceeb4c42b5b0788dc162017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06011-7https://doaj.org/toc/2045-2322Abstract Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown. Our aim was to assess the expression and contribution of Hobit to tissue-residency of Natural Killer (NK) cells in the human liver. The human liver was enriched for CD56bright NK cells showing increased expression levels of the transcription factor Hobit. Hobitpos CD56bright NK cells in the liver exhibited high levels of CD49a, CXCR6 and CD69. Hobitpos CD56bright NK cells in the liver furthermore expressed a unique set of transcription factors with higher frequencies and levels of T-bet and Blimp-1 when compared to Hobitneg CD56bright NK cells. Taken together, we show that the transcription factor Hobit identifies a subset of NK cells in human livers that express a distinct set of adhesion molecules and chemokine receptors consistent with tissue residency. These data suggest that Hobit is involved in regulating tissue-residency of human intrahepatic CD56bright NK cells in a subset of NK cells in inflamed livers.Sebastian LunemannGloria MartrusHanna GoebelsTobias KautzAnnika LangeneckertWilhelm SalzbergerMartina KochMadeleine J. BundersBjörn NashanKlaas P. J. M. van GisbergenMarcus AltfeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Lunemann Gloria Martrus Hanna Goebels Tobias Kautz Annika Langeneckert Wilhelm Salzberger Martina Koch Madeleine J. Bunders Björn Nashan Klaas P. J. M. van Gisbergen Marcus Altfeld Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
description	Abstract Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown. Our aim was to assess the expression and contribution of Hobit to tissue-residency of Natural Killer (NK) cells in the human liver. The human liver was enriched for CD56bright NK cells showing increased expression levels of the transcription factor Hobit. Hobitpos CD56bright NK cells in the liver exhibited high levels of CD49a, CXCR6 and CD69. Hobitpos CD56bright NK cells in the liver furthermore expressed a unique set of transcription factors with higher frequencies and levels of T-bet and Blimp-1 when compared to Hobitneg CD56bright NK cells. Taken together, we show that the transcription factor Hobit identifies a subset of NK cells in human livers that express a distinct set of adhesion molecules and chemokine receptors consistent with tissue residency. These data suggest that Hobit is involved in regulating tissue-residency of human intrahepatic CD56bright NK cells in a subset of NK cells in inflamed livers.
format	article
author	Sebastian Lunemann Gloria Martrus Hanna Goebels Tobias Kautz Annika Langeneckert Wilhelm Salzberger Martina Koch Madeleine J. Bunders Björn Nashan Klaas P. J. M. van Gisbergen Marcus Altfeld
author_facet	Sebastian Lunemann Gloria Martrus Hanna Goebels Tobias Kautz Annika Langeneckert Wilhelm Salzberger Martina Koch Madeleine J. Bunders Björn Nashan Klaas P. J. M. van Gisbergen Marcus Altfeld
author_sort	Sebastian Lunemann
title	Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
title_short	Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
title_full	Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
title_fullStr	Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
title_full_unstemmed	Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells
title_sort	hobit expression by a subset of human liver-resident cd56bright natural killer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c362062aeb504ceeb4c42b5b0788dc16
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Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells

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