DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine

7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine (oxoA) are generated upon oxidative damage to DNA, but the biological effects of oxoA are not well known. Here, the authors report that only oxoA forms DNA interstrand crosslinks (ICLs) upon secondary oxidation and that these ICLs can be induced...

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Autores principales:	Aaron L. Rozelle, Young Cheun, Caroline K. Vilas, Myong-Chul Koag, Seongmin Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c366e0bf70374acd90d59b1e53ec2e99
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spelling	oai:doaj.org-article:c366e0bf70374acd90d59b1e53ec2e992021-12-02T11:44:50ZDNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine10.1038/s41467-021-22273-22041-1723https://doaj.org/article/c366e0bf70374acd90d59b1e53ec2e992021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22273-2https://doaj.org/toc/2041-17237,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine (oxoA) are generated upon oxidative damage to DNA, but the biological effects of oxoA are not well known. Here, the authors report that only oxoA forms DNA interstrand crosslinks (ICLs) upon secondary oxidation and that these ICLs can be induced by reactive halogen species, one-electron oxidants and the myeloperoxidase/H2O2/Cl- system.Aaron L. RozelleYoung CheunCaroline K. VilasMyong-Chul KoagSeongmin LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron L. Rozelle Young Cheun Caroline K. Vilas Myong-Chul Koag Seongmin Lee DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
description	7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine (oxoA) are generated upon oxidative damage to DNA, but the biological effects of oxoA are not well known. Here, the authors report that only oxoA forms DNA interstrand crosslinks (ICLs) upon secondary oxidation and that these ICLs can be induced by reactive halogen species, one-electron oxidants and the myeloperoxidase/H2O2/Cl- system.
format	article
author	Aaron L. Rozelle Young Cheun Caroline K. Vilas Myong-Chul Koag Seongmin Lee
author_facet	Aaron L. Rozelle Young Cheun Caroline K. Vilas Myong-Chul Koag Seongmin Lee
author_sort	Aaron L. Rozelle
title	DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
title_short	DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
title_full	DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
title_fullStr	DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
title_full_unstemmed	DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
title_sort	dna interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c366e0bf70374acd90d59b1e53ec2e99
work_keys_str_mv	AT aaronlrozelle dnainterstrandcrosslinksinducedbythemajoroxidativeadeninelesion78dihydro8oxoadenine AT youngcheun dnainterstrandcrosslinksinducedbythemajoroxidativeadeninelesion78dihydro8oxoadenine AT carolinekvilas dnainterstrandcrosslinksinducedbythemajoroxidativeadeninelesion78dihydro8oxoadenine AT myongchulkoag dnainterstrandcrosslinksinducedbythemajoroxidativeadeninelesion78dihydro8oxoadenine AT seongminlee dnainterstrandcrosslinksinducedbythemajoroxidativeadeninelesion78dihydro8oxoadenine
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DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine

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