Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive...

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Autores principales:	Alejandra Figueroa-Vargas, Claudia Cárcamo, Rodrigo Henríquez-Ch, Francisco Zamorano, Ethel Ciampi, Reinaldo Uribe-San-Martin, Macarena Vásquez, Francisco Aboitiz, Pablo Billeke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3678b7bd47d4e6e8c052f419ee86bdf
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spelling	oai:doaj.org-article:c3678b7bd47d4e6e8c052f419ee86bdf2021-12-02T17:52:42ZFrontoparietal connectivity correlates with working memory performance in multiple sclerosis10.1038/s41598-020-66279-02045-2322https://doaj.org/article/c3678b7bd47d4e6e8c052f419ee86bdf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66279-0https://doaj.org/toc/2045-2322Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.Alejandra Figueroa-VargasClaudia CárcamoRodrigo Henríquez-ChFrancisco ZamoranoEthel CiampiReinaldo Uribe-San-MartinMacarena VásquezFrancisco AboitizPablo BillekeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alejandra Figueroa-Vargas Claudia Cárcamo Rodrigo Henríquez-Ch Francisco Zamorano Ethel Ciampi Reinaldo Uribe-San-Martin Macarena Vásquez Francisco Aboitiz Pablo Billeke Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
description	Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
format	article
author	Alejandra Figueroa-Vargas Claudia Cárcamo Rodrigo Henríquez-Ch Francisco Zamorano Ethel Ciampi Reinaldo Uribe-San-Martin Macarena Vásquez Francisco Aboitiz Pablo Billeke
author_facet	Alejandra Figueroa-Vargas Claudia Cárcamo Rodrigo Henríquez-Ch Francisco Zamorano Ethel Ciampi Reinaldo Uribe-San-Martin Macarena Vásquez Francisco Aboitiz Pablo Billeke
author_sort	Alejandra Figueroa-Vargas
title	Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
title_short	Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
title_full	Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
title_fullStr	Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
title_full_unstemmed	Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
title_sort	frontoparietal connectivity correlates with working memory performance in multiple sclerosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c3678b7bd47d4e6e8c052f419ee86bdf
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Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

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