Erosive cheilitis as an early manifestation in DRESS syndrome

Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) is a distinct part of severe cutaneous adverse reactions (SCARs). It is characterized by fever, rash, hematologic abnormalities, lymphadenopathy, or/and different degrees of visceral organ involvement. Its diagnosis is particular...

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Autores principales:	Wahbi Ben Salha, Eya Moussaoui, Lamia Oualha, Jihed Anoun, Nabiha Douki
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cutaneous adverse reaction DRESS syndrome drug reaction erosive cheilitis oral lesions Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c36c4262cd764e3b800219f7dbf94af9
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spelling	oai:doaj.org-article:c36c4262cd764e3b800219f7dbf94af92021-12-01T06:36:09ZErosive cheilitis as an early manifestation in DRESS syndrome2050-090410.1002/ccr3.5123https://doaj.org/article/c36c4262cd764e3b800219f7dbf94af92021-11-01T00:00:00Zhttps://doi.org/10.1002/ccr3.5123https://doaj.org/toc/2050-0904Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) is a distinct part of severe cutaneous adverse reactions (SCARs). It is characterized by fever, rash, hematologic abnormalities, lymphadenopathy, or/and different degrees of visceral organ involvement. Its diagnosis is particularly challenging due to the variability of its clinical presentations and its long latency period (2–6 weeks). Allopurinol, an uric acid‐lowering drug, has been incriminated in several cases of allopurinol‐induced DRESS syndrome. Through this paper, we present a case of allopurinol‐induced DRESS syndrome with initial oral mucosal involvement. A 69‐year‐old female patient presented with an erosive cheilitis that started 1 week prior to his presentation. The cheilitis was associated with maculopapular rash and fever. She started taking allopurinol, as treatment of Gout, 6 weeks before hospitalization. The histologic findings obtained from skin biopsy were consistent with a toxic drug reaction. A complete blood count (CBC) showed a moderate eosinophilia. Alteration of renal function was also noted, and the diagnosis of allopurinol‐induced DRESS syndrome was made. Systemic corticosteroid therapy was therefore started. The patient completely recovered and had been healthy for 3 years before developing a recurrence after re‐challenge with allopurinol.Wahbi Ben SalhaEya MoussaouiLamia OualhaJihed AnounNabiha DoukiWileyarticlecutaneous adverse reactionDRESS syndromedrug reactionerosive cheilitisoral lesionsMedicineRMedicine (General)R5-920ENClinical Case Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous adverse reaction DRESS syndrome drug reaction erosive cheilitis oral lesions Medicine R Medicine (General) R5-920
spellingShingle	cutaneous adverse reaction DRESS syndrome drug reaction erosive cheilitis oral lesions Medicine R Medicine (General) R5-920 Wahbi Ben Salha Eya Moussaoui Lamia Oualha Jihed Anoun Nabiha Douki Erosive cheilitis as an early manifestation in DRESS syndrome
description	Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) is a distinct part of severe cutaneous adverse reactions (SCARs). It is characterized by fever, rash, hematologic abnormalities, lymphadenopathy, or/and different degrees of visceral organ involvement. Its diagnosis is particularly challenging due to the variability of its clinical presentations and its long latency period (2–6 weeks). Allopurinol, an uric acid‐lowering drug, has been incriminated in several cases of allopurinol‐induced DRESS syndrome. Through this paper, we present a case of allopurinol‐induced DRESS syndrome with initial oral mucosal involvement. A 69‐year‐old female patient presented with an erosive cheilitis that started 1 week prior to his presentation. The cheilitis was associated with maculopapular rash and fever. She started taking allopurinol, as treatment of Gout, 6 weeks before hospitalization. The histologic findings obtained from skin biopsy were consistent with a toxic drug reaction. A complete blood count (CBC) showed a moderate eosinophilia. Alteration of renal function was also noted, and the diagnosis of allopurinol‐induced DRESS syndrome was made. Systemic corticosteroid therapy was therefore started. The patient completely recovered and had been healthy for 3 years before developing a recurrence after re‐challenge with allopurinol.
format	article
author	Wahbi Ben Salha Eya Moussaoui Lamia Oualha Jihed Anoun Nabiha Douki
author_facet	Wahbi Ben Salha Eya Moussaoui Lamia Oualha Jihed Anoun Nabiha Douki
author_sort	Wahbi Ben Salha
title	Erosive cheilitis as an early manifestation in DRESS syndrome
title_short	Erosive cheilitis as an early manifestation in DRESS syndrome
title_full	Erosive cheilitis as an early manifestation in DRESS syndrome
title_fullStr	Erosive cheilitis as an early manifestation in DRESS syndrome
title_full_unstemmed	Erosive cheilitis as an early manifestation in DRESS syndrome
title_sort	erosive cheilitis as an early manifestation in dress syndrome
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c36c4262cd764e3b800219f7dbf94af9
work_keys_str_mv	AT wahbibensalha erosivecheilitisasanearlymanifestationindresssyndrome AT eyamoussaoui erosivecheilitisasanearlymanifestationindresssyndrome AT lamiaoualha erosivecheilitisasanearlymanifestationindresssyndrome AT jihedanoun erosivecheilitisasanearlymanifestationindresssyndrome AT nabihadouki erosivecheilitisasanearlymanifestationindresssyndrome
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Erosive cheilitis as an early manifestation in DRESS syndrome

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