Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan

Abstract Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growi...

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Autores principales:	Keisuke Kamada, Atsushi Yoshida, Shigekazu Iguchi, Yuko Arai, Yutaka Uzawa, Satoshi Konno, Masahiro Shimojima, Ken Kikuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c36e7e36b2134e42beeca1c567afd738
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spelling	oai:doaj.org-article:c36e7e36b2134e42beeca1c567afd7382021-12-02T11:37:25ZGeographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan10.1038/s41598-021-84537-72045-2322https://doaj.org/article/c36e7e36b2134e42beeca1c567afd7382021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84537-7https://doaj.org/toc/2045-2322Abstract Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growing mycobacteria (RGM) species isolated from clinical specimens in Japan and assess differences in the regional distribution of lower respiratory specimens (LRS)- and non-lower respiratory specimens (NLRS)-derived species. 532 strains (427 LRS, 92 NLRS and 15 unknown specimens) were isolated in nine areas of Japan. We collected 418 specimens from Bio Medical Laboratories (BML), Inc., and 114 specimens from 45 hospitals in Japan. Their epidemiological differences were examined according to the specimen type, region, and climate. Fifteen species were identified. The proportion of M. abscessus group (MAG) strains was significantly lower in NLRS than in LRS (35.9% vs. 68.4%). The proportion of MAG strains was higher in northern Japan than in other regions (83.7% vs. 60.5%). Variations in strain abundance among RGM species was evident in regions with a mean annual temperature below 15 °C. We conclude that the proportions of MAG strains differed between NLRS and LRS in Japan. In addition, the mean annual temperature likely influenced the distribution of RGM species.Keisuke KamadaAtsushi YoshidaShigekazu IguchiYuko AraiYutaka UzawaSatoshi KonnoMasahiro ShimojimaKen KikuchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keisuke Kamada Atsushi Yoshida Shigekazu Iguchi Yuko Arai Yutaka Uzawa Satoshi Konno Masahiro Shimojima Ken Kikuchi Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
description	Abstract Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growing mycobacteria (RGM) species isolated from clinical specimens in Japan and assess differences in the regional distribution of lower respiratory specimens (LRS)- and non-lower respiratory specimens (NLRS)-derived species. 532 strains (427 LRS, 92 NLRS and 15 unknown specimens) were isolated in nine areas of Japan. We collected 418 specimens from Bio Medical Laboratories (BML), Inc., and 114 specimens from 45 hospitals in Japan. Their epidemiological differences were examined according to the specimen type, region, and climate. Fifteen species were identified. The proportion of M. abscessus group (MAG) strains was significantly lower in NLRS than in LRS (35.9% vs. 68.4%). The proportion of MAG strains was higher in northern Japan than in other regions (83.7% vs. 60.5%). Variations in strain abundance among RGM species was evident in regions with a mean annual temperature below 15 °C. We conclude that the proportions of MAG strains differed between NLRS and LRS in Japan. In addition, the mean annual temperature likely influenced the distribution of RGM species.
format	article
author	Keisuke Kamada Atsushi Yoshida Shigekazu Iguchi Yuko Arai Yutaka Uzawa Satoshi Konno Masahiro Shimojima Ken Kikuchi
author_facet	Keisuke Kamada Atsushi Yoshida Shigekazu Iguchi Yuko Arai Yutaka Uzawa Satoshi Konno Masahiro Shimojima Ken Kikuchi
author_sort	Keisuke Kamada
title	Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_short	Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_full	Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_fullStr	Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_full_unstemmed	Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_sort	geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in japan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c36e7e36b2134e42beeca1c567afd738
work_keys_str_mv	AT keisukekamada geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT atsushiyoshida geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT shigekazuiguchi geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT yukoarai geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT yutakauzawa geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT satoshikonno geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT masahiroshimojima geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan AT kenkikuchi geographicaldistributionandregionaldifferencesin532clinicalisolatesofrapidlygrowingmycobacterialspeciesinjapan
_version_	1718395786170990592

Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan

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