Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c371d2526a5d4d4fbe8ed4cc2103dcb3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c371d2526a5d4d4fbe8ed4cc2103dcb3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c371d2526a5d4d4fbe8ed4cc2103dcb32021-12-02T15:45:30ZSevere T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes10.1038/s41467-021-23334-22041-1723https://doaj.org/article/c371d2526a5d4d4fbe8ed4cc2103dcb32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23334-2https://doaj.org/toc/2041-1723Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.Kerstin RennerTobias SchwittaySophia ChaabaneJohanna GottschlingChristine MüllerCharlotte TiefenböckJan-Niklas SalewskiFrederike WinterSimone BuchtlerSaidou BalamMaximilian V. MalfertheinerMatthias LubnowDirk LunzBernhard GrafFlorian HitzenbichlerFrank HansesHendrik PoeckMarina KreutzEvelyn OrsóRalph BurkhardtTanja NiedermairChristoph BrochhausenAndré GessnerBernd SalzbergerMatthias MackNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| description |
Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence. |
| format |
article |
| author |
Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack |
| author_facet |
Kerstin Renner Tobias Schwittay Sophia Chaabane Johanna Gottschling Christine Müller Charlotte Tiefenböck Jan-Niklas Salewski Frederike Winter Simone Buchtler Saidou Balam Maximilian V. Malfertheiner Matthias Lubnow Dirk Lunz Bernhard Graf Florian Hitzenbichler Frank Hanses Hendrik Poeck Marina Kreutz Evelyn Orsó Ralph Burkhardt Tanja Niedermair Christoph Brochhausen André Gessner Bernd Salzberger Matthias Mack |
| author_sort |
Kerstin Renner |
| title |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_short |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_full |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_fullStr |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_full_unstemmed |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
| title_sort |
severe t cell hyporeactivity in ventilated covid-19 patients correlates with prolonged virus persistence and poor outcomes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c371d2526a5d4d4fbe8ed4cc2103dcb3 |
| work_keys_str_mv |
AT kerstinrenner severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT tobiasschwittay severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT sophiachaabane severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT johannagottschling severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT christinemuller severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT charlottetiefenbock severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT janniklassalewski severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT frederikewinter severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT simonebuchtler severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT saidoubalam severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT maximilianvmalfertheiner severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT matthiaslubnow severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT dirklunz severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT bernhardgraf severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT florianhitzenbichler severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT frankhanses severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT hendrikpoeck severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT marinakreutz severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT evelynorso severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT ralphburkhardt severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT tanjaniedermair severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT christophbrochhausen severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT andregessner severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT berndsalzberger severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes AT matthiasmack severetcellhyporeactivityinventilatedcovid19patientscorrelateswithprolongedviruspersistenceandpooroutcomes |
| _version_ |
1718385776415211520 |