Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections

Nick Larsen et al. developed a pipeline to collect and image serial sections from fixed human cortex, then apply deep learning to detect pyramidal cells from 3D reconstructions of these sections. Their results reiterate that cortical pyramidal cells are organized in a columnar structure and highligh...

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Autores principales:	Nick Y. Larsen, Xixia Li, Xueke Tan, Gang Ji, Jing Lin, Grazyna Rajkowska, Jesper Møller, Ninna Vihrs, Jon Sporring, Fei Sun, Jens R. Nyengaard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c372f12dc5a442998736c0ade347fe0e
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spelling	oai:doaj.org-article:c372f12dc5a442998736c0ade347fe0e2021-12-02T16:38:23ZCellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections10.1038/s42003-021-02548-62399-3642https://doaj.org/article/c372f12dc5a442998736c0ade347fe0e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02548-6https://doaj.org/toc/2399-3642Nick Larsen et al. developed a pipeline to collect and image serial sections from fixed human cortex, then apply deep learning to detect pyramidal cells from 3D reconstructions of these sections. Their results reiterate that cortical pyramidal cells are organized in a columnar structure and highlight the potential of this method, which is universally applicable to characterize cells for various tissues.Nick Y. LarsenXixia LiXueke TanGang JiJing LinGrazyna RajkowskaJesper MøllerNinna VihrsJon SporringFei SunJens R. NyengaardNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nick Y. Larsen Xixia Li Xueke Tan Gang Ji Jing Lin Grazyna Rajkowska Jesper Møller Ninna Vihrs Jon Sporring Fei Sun Jens R. Nyengaard Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
description	Nick Larsen et al. developed a pipeline to collect and image serial sections from fixed human cortex, then apply deep learning to detect pyramidal cells from 3D reconstructions of these sections. Their results reiterate that cortical pyramidal cells are organized in a columnar structure and highlight the potential of this method, which is universally applicable to characterize cells for various tissues.
format	article
author	Nick Y. Larsen Xixia Li Xueke Tan Gang Ji Jing Lin Grazyna Rajkowska Jesper Møller Ninna Vihrs Jon Sporring Fei Sun Jens R. Nyengaard
author_facet	Nick Y. Larsen Xixia Li Xueke Tan Gang Ji Jing Lin Grazyna Rajkowska Jesper Møller Ninna Vihrs Jon Sporring Fei Sun Jens R. Nyengaard
author_sort	Nick Y. Larsen
title	Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
title_short	Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
title_full	Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
title_fullStr	Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
title_full_unstemmed	Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
title_sort	cellular 3d-reconstruction and analysis in the human cerebral cortex using automatic serial sections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c372f12dc5a442998736c0ade347fe0e
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Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections

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