Aberrant functional connectivity in depression as an index of state and trait rumination

Abstract Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain...

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Autores principales:	David Rosenbaum, Alina Haipt, Kristina Fuhr, Florian B. Haeussinger, Florian G. Metzger, Hans-Christoph Nuerk, Andreas J. Fallgatter, Anil Batra, Ann-Christine Ehlis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c373d6f85cca4bf687dfb3d988634ec2
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spelling	oai:doaj.org-article:c373d6f85cca4bf687dfb3d988634ec22021-12-02T16:06:57ZAberrant functional connectivity in depression as an index of state and trait rumination10.1038/s41598-017-02277-z2045-2322https://doaj.org/article/c373d6f85cca4bf687dfb3d988634ec22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02277-zhttps://doaj.org/toc/2045-2322Abstract Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.David RosenbaumAlina HaiptKristina FuhrFlorian B. HaeussingerFlorian G. MetzgerHans-Christoph NuerkAndreas J. FallgatterAnil BatraAnn-Christine EhlisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Rosenbaum Alina Haipt Kristina Fuhr Florian B. Haeussinger Florian G. Metzger Hans-Christoph Nuerk Andreas J. Fallgatter Anil Batra Ann-Christine Ehlis Aberrant functional connectivity in depression as an index of state and trait rumination
description	Abstract Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.
format	article
author	David Rosenbaum Alina Haipt Kristina Fuhr Florian B. Haeussinger Florian G. Metzger Hans-Christoph Nuerk Andreas J. Fallgatter Anil Batra Ann-Christine Ehlis
author_facet	David Rosenbaum Alina Haipt Kristina Fuhr Florian B. Haeussinger Florian G. Metzger Hans-Christoph Nuerk Andreas J. Fallgatter Anil Batra Ann-Christine Ehlis
author_sort	David Rosenbaum
title	Aberrant functional connectivity in depression as an index of state and trait rumination
title_short	Aberrant functional connectivity in depression as an index of state and trait rumination
title_full	Aberrant functional connectivity in depression as an index of state and trait rumination
title_fullStr	Aberrant functional connectivity in depression as an index of state and trait rumination
title_full_unstemmed	Aberrant functional connectivity in depression as an index of state and trait rumination
title_sort	aberrant functional connectivity in depression as an index of state and trait rumination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c373d6f85cca4bf687dfb3d988634ec2
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Aberrant functional connectivity in depression as an index of state and trait rumination

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