Lower mean platelet volume predicts poor prognosis in renal cell carcinoma

Abstract Altered mean platelet volume (MPV) is found in several malignancies. Remarkably, there is little consensus on using the value of MPV in the prognostic evaluations of renal cell carcinoma (RCC). The aim of this study is to examine the feasibility of MPV value as a prognostic indicator of RCC...

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Autores principales:	Zhi-yuan Yun, Xin Zhang, Yan-song Liu, Tiemin Liu, Zhi-ping Liu, Rui-tao Wang, Kai-jiang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c37532f160f344d688a99c2aa8a69f8d
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spelling	oai:doaj.org-article:c37532f160f344d688a99c2aa8a69f8d2021-12-02T15:05:51ZLower mean platelet volume predicts poor prognosis in renal cell carcinoma10.1038/s41598-017-07168-x2045-2322https://doaj.org/article/c37532f160f344d688a99c2aa8a69f8d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07168-xhttps://doaj.org/toc/2045-2322Abstract Altered mean platelet volume (MPV) is found in several malignancies. Remarkably, there is little consensus on using the value of MPV in the prognostic evaluations of renal cell carcinoma (RCC). The aim of this study is to examine the feasibility of MPV value as a prognostic indicator of RCC. The retrospective study recruited 306 consecutive RCC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 306 RCC patients, low MPV levels were detected in 61 (19.9%) patients. Reduced MPV was associated with histology types, T classification, UCLA Integrated Scoring System (UISS) category, and Mayo clinic stage, size, grade, and necrosis score (SSIGN) category (P < 0.05). Patients with decreased MPV had significantly shorter survival time than patients with normal MPV (P < 0.001). Cox regression analysis revealed that reduced MPV was an independent prognostic factor for overall survival (hazard ratio, 1.758; 95% confidence interval [CI], 1.083–2.855, P = 0.023). Moreover, the prognostic accuracy of TNM stage, UISS, and SSIGN prognostic models were improved when MPV was added. In conclusion, reduced MPV is identified as an independent predictor of adverse clinical outcome in RCC.Zhi-yuan YunXin ZhangYan-song LiuTiemin LiuZhi-ping LiuRui-tao WangKai-jiang YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi-yuan Yun Xin Zhang Yan-song Liu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
description	Abstract Altered mean platelet volume (MPV) is found in several malignancies. Remarkably, there is little consensus on using the value of MPV in the prognostic evaluations of renal cell carcinoma (RCC). The aim of this study is to examine the feasibility of MPV value as a prognostic indicator of RCC. The retrospective study recruited 306 consecutive RCC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 306 RCC patients, low MPV levels were detected in 61 (19.9%) patients. Reduced MPV was associated with histology types, T classification, UCLA Integrated Scoring System (UISS) category, and Mayo clinic stage, size, grade, and necrosis score (SSIGN) category (P < 0.05). Patients with decreased MPV had significantly shorter survival time than patients with normal MPV (P < 0.001). Cox regression analysis revealed that reduced MPV was an independent prognostic factor for overall survival (hazard ratio, 1.758; 95% confidence interval [CI], 1.083–2.855, P = 0.023). Moreover, the prognostic accuracy of TNM stage, UISS, and SSIGN prognostic models were improved when MPV was added. In conclusion, reduced MPV is identified as an independent predictor of adverse clinical outcome in RCC.
format	article
author	Zhi-yuan Yun Xin Zhang Yan-song Liu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu
author_facet	Zhi-yuan Yun Xin Zhang Yan-song Liu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu
author_sort	Zhi-yuan Yun
title	Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
title_short	Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
title_full	Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
title_fullStr	Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
title_full_unstemmed	Lower mean platelet volume predicts poor prognosis in renal cell carcinoma
title_sort	lower mean platelet volume predicts poor prognosis in renal cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c37532f160f344d688a99c2aa8a69f8d
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Lower mean platelet volume predicts poor prognosis in renal cell carcinoma

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