Association of FTO and PPARG polymorphisms with obesity in Portuguese women

Fábio Ferreira Carlos,1,2 José Silva-Nunes,3,4 Orfeu Flores,1 Miguel Brito,3 Gonçalo Doria,1 Luísa Veiga,3 Pedro Viana Baptista1 1Centro de Investigação em Genética Molecular Humana, Universidade Nova de Lisboa, Caparica, P...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ferreira Carlos F, Silva-Nunes J, Flores O, Brito M, Doria G, Veiga L, Baptista PV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c37b0df1357449238e27731b3a307685
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c37b0df1357449238e27731b3a307685
record_format	dspace
spelling	oai:doaj.org-article:c37b0df1357449238e27731b3a3076852021-12-02T06:33:16ZAssociation of FTO and PPARG polymorphisms with obesity in Portuguese women1178-7007https://doaj.org/article/c37b0df1357449238e27731b3a3076852013-07-01T00:00:00Zhttp://www.dovepress.com/association-of-fto-and-pparg-polymorphisms-with-obesity-in-portuguese--a13652https://doaj.org/toc/1178-7007Fábio Ferreira Carlos,1,2 José Silva-Nunes,3,4 Orfeu Flores,1 Miguel Brito,3 Gonçalo Doria,1 Luísa Veiga,3 Pedro Viana Baptista1 1Centro de Investigação em Genética Molecular Humana, Universidade Nova de Lisboa, Caparica, Portugal; 2Investigação e Serviços em Ciências Biológicas, Stab Vida, Caparica, Portugal; 3Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal; 4Endocrinology Department, Curry Cabral Hospital, Lisbon, Portugal Purpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥30 g/m2, 99 controls with BMI 18.5–24.9 kg/m2) participated in this study. The association of the single-nucleotide polymorphisms with obesity was determined by odds ratio calculation with 95% confidence intervals. Results: Significant differences in allelic expression of FTO rs9939609 (P<0.05) were found between control and case groups, indicating a 2.5-higher risk for obesity in the presence of both risk alleles when comparing the control group with the entire obese group. A fourfold-higher risk was found for subjects with class III obesity compared to those with classes I and II. No significant differences in BMI were found between the control and case groups for PPARG rs1801282 (P>0.05). Conclusion: For the first time, a study involving an adult Portuguese population shows that individuals harboring both risk alleles in the FTO gene locus are at higher risk for obesity, which is in agreement to what has been reported for other European populations. Keywords: rs9939609, rs1801282, BMI, SNP, odds ratioFerreira Carlos FSilva-Nunes JFlores OBrito MDoria GVeiga LBaptista PVDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 241-245 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Ferreira Carlos F Silva-Nunes J Flores O Brito M Doria G Veiga L Baptista PV Association of FTO and PPARG polymorphisms with obesity in Portuguese women
description	Fábio Ferreira Carlos,1,2 José Silva-Nunes,3,4 Orfeu Flores,1 Miguel Brito,3 Gonçalo Doria,1 Luísa Veiga,3 Pedro Viana Baptista1 1Centro de Investigação em Genética Molecular Humana, Universidade Nova de Lisboa, Caparica, Portugal; 2Investigação e Serviços em Ciências Biológicas, Stab Vida, Caparica, Portugal; 3Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal; 4Endocrinology Department, Curry Cabral Hospital, Lisbon, Portugal Purpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥30 g/m2, 99 controls with BMI 18.5–24.9 kg/m2) participated in this study. The association of the single-nucleotide polymorphisms with obesity was determined by odds ratio calculation with 95% confidence intervals. Results: Significant differences in allelic expression of FTO rs9939609 (P<0.05) were found between control and case groups, indicating a 2.5-higher risk for obesity in the presence of both risk alleles when comparing the control group with the entire obese group. A fourfold-higher risk was found for subjects with class III obesity compared to those with classes I and II. No significant differences in BMI were found between the control and case groups for PPARG rs1801282 (P>0.05). Conclusion: For the first time, a study involving an adult Portuguese population shows that individuals harboring both risk alleles in the FTO gene locus are at higher risk for obesity, which is in agreement to what has been reported for other European populations. Keywords: rs9939609, rs1801282, BMI, SNP, odds ratio
format	article
author	Ferreira Carlos F Silva-Nunes J Flores O Brito M Doria G Veiga L Baptista PV
author_facet	Ferreira Carlos F Silva-Nunes J Flores O Brito M Doria G Veiga L Baptista PV
author_sort	Ferreira Carlos F
title	Association of FTO and PPARG polymorphisms with obesity in Portuguese women
title_short	Association of FTO and PPARG polymorphisms with obesity in Portuguese women
title_full	Association of FTO and PPARG polymorphisms with obesity in Portuguese women
title_fullStr	Association of FTO and PPARG polymorphisms with obesity in Portuguese women
title_full_unstemmed	Association of FTO and PPARG polymorphisms with obesity in Portuguese women
title_sort	association of fto and pparg polymorphisms with obesity in portuguese women
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c37b0df1357449238e27731b3a307685
work_keys_str_mv	AT ferreiracarlosf associationofftoandppargpolymorphismswithobesityinportuguesewomen AT silvanunesj associationofftoandppargpolymorphismswithobesityinportuguesewomen AT floreso associationofftoandppargpolymorphismswithobesityinportuguesewomen AT britom associationofftoandppargpolymorphismswithobesityinportuguesewomen AT doriag associationofftoandppargpolymorphismswithobesityinportuguesewomen AT veigal associationofftoandppargpolymorphismswithobesityinportuguesewomen AT baptistapv associationofftoandppargpolymorphismswithobesityinportuguesewomen
_version_	1718399898567573504

Association of FTO and PPARG polymorphisms with obesity in Portuguese women

Ejemplares similares