A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner

Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport. Here, the authors present the crystal structures of two adaptor complexes with the dynein light intermediate chain-1 (LIC1) a...

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Autores principales:	In-Gyun Lee, Sydney E. Cason, Saif S. Alqassim, Erika L. F. Holzbaur, Roberto Dominguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c37c321a46f94c168a714462f73c6d6f
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id	oai:doaj.org-article:c37c321a46f94c168a714462f73c6d6f
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spelling	oai:doaj.org-article:c37c321a46f94c168a714462f73c6d6f2021-12-02T15:37:07ZA tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner10.1038/s41467-020-19538-72041-1723https://doaj.org/article/c37c321a46f94c168a714462f73c6d6f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19538-7https://doaj.org/toc/2041-1723Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport. Here, the authors present the crystal structures of two adaptor complexes with the dynein light intermediate chain-1 (LIC1) and show that activating adaptors can be grouped into three structural classes based on their different interactions with LIC1.In-Gyun LeeSydney E. CasonSaif S. AlqassimErika L. F. HolzbaurRoberto DominguezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q In-Gyun Lee Sydney E. Cason Saif S. Alqassim Erika L. F. Holzbaur Roberto Dominguez A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
description	Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport. Here, the authors present the crystal structures of two adaptor complexes with the dynein light intermediate chain-1 (LIC1) and show that activating adaptors can be grouped into three structural classes based on their different interactions with LIC1.
format	article
author	In-Gyun Lee Sydney E. Cason Saif S. Alqassim Erika L. F. Holzbaur Roberto Dominguez
author_facet	In-Gyun Lee Sydney E. Cason Saif S. Alqassim Erika L. F. Holzbaur Roberto Dominguez
author_sort	In-Gyun Lee
title	A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
title_short	A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
title_full	A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
title_fullStr	A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
title_full_unstemmed	A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
title_sort	tunable lic1-adaptor interaction modulates dynein activity in a cargo-specific manner
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c37c321a46f94c168a714462f73c6d6f
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A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner

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